McIntosh Lab

McIntosh Lab

Relationship Between Mitochondrial Damage and Endothelial Dysfunction and Subsequent Development of Preeclampsia

Maternal and neonatal morbidity and mortality caused by preeclampsia is a significant global health burden with approximately 10 million pregnancies impacted resulting in nearly half a million fetal or neonatal lives lost each year. A novel relationship may exist between mitochondrial damage and endothelial dysfunction and subsequent development of preeclampsia.

Our overall goal is to investigate the mechanism whereby placental hypoxia is responsible for release of ROS and inflammation secondary to mitochondrial DNA (mtDNA) and if there is altered FMD as a result of heightened mtDNA in vessels from placentas in those with preeclampsia.

Principal Investigator

Jennifer McIntosh, DO, MS

McIntosh, Jennifer Jury, DO, MS

Assistant ProfessorSpecialty: Maternal-Fetal Medicine

Read More ›

Lab Staff

Derayunan, Alexa

Derayunan, Alexa

Research Technologist – Dr. McIntosh’s Lab
(414) 955-4147

Read More ›

In the News

Dr. Jennifer McIntosh Awarded CTSI Grant on

Dr. Jennifer McIntosh Awarded CTSI Grant on “Effects of Preeclampsia and Preterm Birth on Maternal Endothelial Function”

Jennifer McIntosh, DO, MS

Along with Drs. Jacquelyn P. Kulinski and Nicole Lohr, Dr. Jennifer McIntosh has been awarded the Clinical &… Read More ›

Rounding with the Dean: Knowledge Changing Life in the Department of Obstetrics & Gynecology

Rounding with the Dean: Knowledge Changing Life in the Department of Obstetrics & Gynecology

Josepah E. Kerschner, MD

On October 4, 2017, Josepah E. Kerschner, MD, Dean of the School of Medicine at the Medical College… Read More ›

Dr. Jennifer McIntosh one of the study authors of Platelet Counts during Pregnancy in the New England Journal of Medicine

Dr. Jennifer McIntosh one of the study authors of Platelet Counts during Pregnancy in the New England Journal of Medicine

Jennifer McIntosh, DO, MS

Jennifer McIntosh, DO, Assistant Professor in Maternal-Fetal Medicine, is one of the study authors of a paper in… Read More ›

Drs. Jenn McIntosh and Anna Palatnik both chosen to give presentations on their Research at the SMFM Annual Conference

Drs. Jenn McIntosh and Anna Palatnik both chosen to give presentations on their Research at the SMFM Annual Conference

The Society for Maternal-Fetal Medicine (SMFM) annual meeting has become known for its groundbreaking research presentations. This year, there was 1,015 oral and poster presentations… Read More ›

 

Medical College of Wisconsin,
Department of Obstetrics & Gynecology
9200 West Wisconsin Ave.,
Milwaukee, WI 53226-3522
Phone: (414) 805-6600
24-Hour Emergency Line: (414) 805-6700

Children's Hospital of Wisconsin

© 2012 - 2019, Medical College of Wisconsin, Department of Obstetrics and Gynecology. | Home | Site Map | Contact Us

twitter facebook