Chen, Guangbo (Bill), PhD
Assistant Professor
Guangbo (Bill) Chen, PhD joined the Medical College of Wisconsin in the Department of Obstetrics and Gynecology as an Assistant Professor. He obtained his PhD in Molecular and Integrative Physiology from the University of Kansas, working with Dr. Rong Li at Stowers Institute for Medical Research. His seminal works on aneuploidy (published in Nature and Cell) earned him the Kaluza Prize of Excellence in Graduate Research from the American Society of Cell Biology, sponsored by Beckman Coulter. He then finished a Life Science Research Foundation fellowship (Sponsored by Eli Lilly) in Mark Davis’s lab at Stanford University. This fellowship allowed him to explore a new field: human immunology. He learned a novel system (spleen organoid) newly established in Davis lab and enabled it for high-throughput screening.
Education / Training
- PhD in Molecular and Integrative Physiology – University of Kansas Medical Center
- Postdoctoral Eli Lilly Fellow of Life Science Research – Stanford University
Research Interest
- Human Immunology: Use spleen from organ donor and high-throughput screening to understand the immune mechanisms
- Vaccine: Inform rationale design of vaccines
Chen G, Mohsin A, Zheng H, Rosenberg-Hasson Y, Padilla C, Sarin KY, Dekker CL, Grant P, Maecker HT, Lu Y, Furman D, Shen-Orr S, Khatri P, Davis MM. Age-dependent cytokine surge in blood precedes cancer diagnosis. Proc Natl Acad Sci U S A. 2025 Mar 25;122(12):e2420502122 PMID: 40117305 PMCID: PMC11962427 03/21/2025
Chen G, Deutsch GH, Schulert GS, Zheng H, Jang S, Trapnell B, Lee PY, Macaubas C, Ho K, Schneider C, Saper VE, de Jesus AA, Krasnow MA, Grom A, Goldbach-Mansky R, Khatri P, Mellins ED, Canna SW. Identification of Distinct Inflammatory Programs and Biomarkers in Systemic Juvenile Idiopathic Arthritis and Related Lung Disease by Serum Proteome Analysis. Arthritis Rheumatol. 2022 Jul;74(7):1271-1283 PMID: 35189047 PMCID: PMC9246966 02/22/2022
Saper VE, Chen G, Guillerman RP, Khatri P, Cron RQ, Mellins ED. Response to: 'Successful treatment of plasma exchange for refractory systemic juvenile idiopathic arthritis complicated with macrophage activation syndrome and severe lung disease' by Sato et al. Ann Rheum Dis. 2022 Apr;81(4):e62 PMID: 32317313 04/23/2020
Saper VE, Chen G, Khatri P, Mellins ED. Response to: 'Effectiveness and safety of ruxolitinib for the treatment of refractory systemic idiopathic juvenile arthritis like associated with interstitial lung disease: case report' by Bader-Meunier et al. Ann Rheum Dis. 2022 Feb;81(2):e21 PMID: 32054603 02/15/2020
Saper VE, Chen G, Deutsch GH, Guillerman RP, Birgmeier J, Jagadeesh K, Canna S, Schulert G, Deterding R, Xu J, Leung AN, Bouzoubaa L, Abulaban K, Baszis K, Behrens EM, Birmingham J, Casey A, Cidon M, Cron RQ, De A, De Benedetti F, Ferguson I, Fishman MP, Goodman SI, Graham TB, Grom AA, Haines K, Hazen M, Henderson LA, Ho A, Ibarra M, Inman CJ, Jerath R, Khawaja K, Kingsbury DJ, Klein-Gitelman M, Lai K, Lapidus S, Lin C, Lin J, Liptzin DR, Milojevic D, Mombourquette J, Onel K, Ozen S, Perez M, Phillippi K, Prahalad S, Radhakrishna S, Reinhardt A, Riskalla M, Rosenwasser N, Roth J, Schneider R, Schonenberg-Meinema D, Shenoi S, Smith JA, Sönmez HE, Stoll ML, Towe C, Vargas SO, Vehe RK, Young LR, Yang J, Desai T, Balise R, Lu Y, Tian L, Bejerano G, Davis MM, Khatri P, Mellins ED, Childhood Arthritis and Rheumatology Research Alliance Registry Investigators. Emergent high fatality lung disease in systemic juvenile arthritis. Ann Rheum Dis. 2019 Dec;78(12):1722-1731 PMID: 31562126 PMCID: PMC7065839 09/29/2019
Chen G, Mulla WA, Kucharavy A, Tsai HJ, Rubinstein B, Conkright J, McCroskey S, Bradford WD, Weems L, Haug JS, Seidel CW, Berman J, Li R. Targeting the adaptability of heterogeneous aneuploids. Cell. 2015 Feb 12;160(4):771-784 PMID: 25679766 PMCID: PMC4328141 02/14/2015
Chen G, Rubinstein B, Li R. Whole chromosome aneuploidy: big mutations drive adaptation by phenotypic leap. Bioessays. 2012 Oct;34(10):893-900 PMID: 22926916 PMCID: PMC3526072 08/29/2012
Chen G, Bradford WD, Seidel CW, Li R. Hsp90 stress potentiates rapid cellular adaptation through induction of aneuploidy. Nature. 2012 Jan 29;482(7384):246-50 PMID: 22286062 PMCID: PMC3276732 01/31/2012
Publications of Guangbo Chen PhD from the Faculty Collaboration Database