Parashar, Deepak, PhD

Postdoc Fellow – Dr. Pradeep Chaluvally-Raghavan’s Lab

(414) 955-2564

I am interested in identifying the mechanisms of oncogenic microRNA 551b (miR551b) on tumor growth and tumor specific angiogenesis in both tumor cells and tumor microenvironment. MicroRNAs (miRNAs) are a class of endogenous noncoding RNA and post transcriptionally modulate gene expression during development and disease including cancer. The thematic focus of my research interest is to investigate our hypothesis that anti-microRNAs target and inhibit miR551b, plays a key role in suppressing pro-inflammatory pathways, involving STAT3, HIF1 alpha and VEGF, through regulating Oncostatin signaling. We are expecting that miR551b or its target may represent as a new novel therapeutic target in the search for ways to reverse the resistance towards anti-VEGF therapies.

Lab

Chaluvally Lab

Chaluvally Lab

Copy number variations (CNVs) such as deletions or amplifications of chromosomal loci are common events during the initiation and progression of cancer. While…

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