Ramchandran Lab

Ramchandran Lab

Dr. Ramchandran’s lab is involved in gynecologic cancer research with a specific focus on the role of metabolism in gynecological cancer. Dr. Ramchandran collaborates extensively with faculty in OBGYN, and projects ongoing in the lab that are related to these collaborations are described below.

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Little is understood about how ovarian cancer spreads and the lab is studying how ovarian cancer cells spread both locally within the abdominal cavity and distantly through the blood stream. Due to the predilection for ovarian cancer cells to spread to the omentum, which is a tissue in the abdomen mainly comprised of fat cells, one focus of the lab is to further understand the metabolism of ovarian cancer cells as it relates to fat. This is being done by investigating and altering various pathways involved in tumor growth and metabolism. In collaboration with Dr. Erin Bishop, Assistant Professor in OBGYN, the lab is focused on studying ovarian cancer spheroids, or clumps of cells, that form when they break off of the ovary and spread within the abdominal cavity. Ovarian cancer spheroids are thought to be more resistant to treatment than single ovarian cancer cells. The lab is working on understanding proteins involved in spheroid formation and metastasis with the goal of discovering ways to alter their behavior that will lead to new therapies for ovarian cancer that include spheroids as a target.

Patients with BRCA1 mutations either in breast cancer or ovarian cancer show highest incidence of brain mets, which suggest that breast cancer and ovarian cancer may share some common mechanisms to metastasis to the brain. This project is developed in collaboration with Dr. Ling Wang, Assistant Professor in OBGYN. Tumor metastasis is the outcome of interaction of metastasizing cells with the environment of specific organs. We are investigating the interaction of the brain microenvironment with breast and ovarian cancer cells in facilitating brain metastasis.

A second metabolic associated project includes the endothelial cell specific chemotaxis receptor (ECSCR), a cell surface protein expressed in adipocytes, which was previously reported by Drs. Ramchandran and George Wilkinson as a molecule that influence VEGFR2 receptor signaling on endothelial cells. Dr. Ramchandran collaborates with Dr. Yi-Wen Huang, OBGYN faculty to investigate the role of ECSCR and PTEN signaling in obesity induced endometrial cancer tumorigenesis.

Finally, Dr. Ramchandran’s lab in collaboration with Chair of OBGYN Dr. Janet Rader is studying the role of angiogenesis and lymphangiogenesis associated with cervical cancer progression. They are specifically focused on the mechanistic role associated with Robos in mediating cervical cancer progression and metastasis.

Principal Investigator

Ramchandran, Ramani, PhD

Ramchandran, Ramani, PhD

Patrick J. and Margaret G. McMahon endowed Professor and Vice Chair of Research
(414) 955-2387

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OBGYN Postdoc Fellow

In the News

Dr. Ramchandran Receives SAASCR Award for his Cancer Research

Dr. Ramchandran Receives SAASCR Award for his Cancer Research

Ramani Ramchandran, PhD, was one of nine Indian American Scientists honored by Society of Asian American Scientists Cancer Research (SAASCR) for his outstanding contributions to… Read More ›

Dr. Ramchandran to Study Novel Regulatory Mechanisms for a Gene Involved in Vascular Anomalies

Dr. Ramchandran to Study Novel Regulatory Mechanisms for a Gene Involved in Vascular Anomalies

The Medical College of Wisconsin (MCW) has received a four-year, $1.8 million dollar grant from the National Institutes of Health’s National Heart, Lung and Blood… Read More ›

Ramani Ramchandran, PhD receives MCW's Faculty Innovator Award

Ramani Ramchandran, PhD receives MCW’s Faculty Innovator Award

Ramani Ramchandran, PhD

Ramani Ramchandran, PhD, OBGYN’s Patrick J. and Margaret G. McMahon endowed Professor and Vice Chair of Research, received the… Read More ›

Dr. Erin Bishop Receives Mentored Career Development Award

Dr. Erin Bishop Receives Mentored Career Development Award

The CTSI Mentored Career Development (KL2) Award provides training opportunities for junior faculty working in clinical and translational research to become independent investigators. The program… Read More ›

Translational Research – It Takes Two to Tango!

Translational Research – It Takes Two to Tango!

06/16/2014  |  Department News

Currently, translational research remains the focus for the majority of academic researchers at United States institutions. The emphasis on translational research is directly the result… Read More ›

Welcome Ramani Ramchandran, PhD in Obstetrics and Gynecology

Welcome Ramani Ramchandran, PhD in Obstetrics and Gynecology

10/16/2013  |  Department News

Dr. Ramani Ramchandran, PhD has been appointed the Patrick J. and Margaret G. McMahon endowed Professor and Vice Chair of Research.

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Ramani Ramchandran, PhD Received the Distinguished Alumnus Award from Georgia Regents University College of Graduate Studies

Ramani Ramchandran, PhD Received the Distinguished Alumnus Award from Georgia Regents University College of Graduate Studies

09/18/2013  |  Awards & Recognition

Georgia Regents University recognized distinguished alumni during the university’s homecoming activities in February and Alumni Weekend in April 2013.

Dr. Ramani Ramchandran, Director of the Developmental… Read More ›