Dr. Ramchandran’s lab is involved in gynecologic cancer research with a specific focus on the role of metabolism in gynecological cancer. Dr. Ramchandran collaborates extensively with faculty in OBGYN, and projects ongoing in the lab that are related to these collaborations are described below.
Little is understood about how ovarian cancer spreads and the lab is studying how ovarian cancer cells spread both locally within the abdominal cavity and distantly through the blood stream. Due to the predilection for ovarian cancer cells to spread to the omentum, which is a tissue in the abdomen mainly comprised of fat cells, one focus of the lab is to further understand the metabolism of ovarian cancer cells as it relates to fat. This is being done by investigating and altering various pathways involved in tumor growth and metabolism.