The big picture goal of the Ojesina Oncopathogenomics Laboratory is to investigate the underlying causes of cancer to identify better ways to prevent, diagnose and treat cancer.
Specifically, we investigate tumors as an ecosystem in which microbes (viruses, bacteria, etc) synergize with genomic alterations to influence tumor initiation, progression, response to therapy and prognosis. This knowledge gained using this “tumor ecology” paradigm will then be translated into improvements in cancer prevention, diagnosis and therapy.
In order to answer these questions, we apply a combination of cutting-edge genomic analyses and laboratory experiments to interrogate relevant population-based patient samples, laboratory cell lines and animal models. Although we are interested in a wide variety of cancers, our primary focus is on infection-related cancers, HPV-associated squamous cell carcinomas and women’s cancers like breast cancer and cervical cancer (Nature 2014;506:371, Nature 2017;543:378, Nature Genetics 2020;52:800, Cancers 2021;13:4551, npj Genomic Medicine 2021;6:82).