The role of spheroids in ovarian cancer metastasis and resistance to treatment
Ovarian cancer is uniquely characterized by early metastasis throughout the peritoneal cavity making a better understanding of the metastatic process essential for finding better treatment options. Clusters of ovarian cancer cells, or “spheroids,” have been suggested to play a key role in ovarian cancer metastasis, and are thought to protect cells from treatment resulting in recurrent disease. The clinical importance of spheroids is poorly understood. The goal of my research is to understand the interaction between ovarian cancer spheroids and the mesothelium that lines the peritoneal cavity in order to determine how spheroids play a role in ovarian cancer metastasis and resistance to treatment.