02 Dec Jasmine George, PhD, postdoctoral fellow of Pradeep Chaluvally-Raghavan, PhD, receives grant on “Chemoresistance Mechanism Orchestrated through FXR1 in Ovarian Cancer”
Jasmine George, PhD, postdoctoral fellow of Pradeep Chaluvally-Raghavan, PhD, received the inaugural postdoctoral fellowship grant from the Medical College of Wisconsin Cancer Center for her research on “Chemoresistance Mechanism Orchestrated through FXR1 in Ovarian Cancer”.
Dr. George has reported in the past that FXR1 promotes the translation of several oncogenic proteins, including MYC, by aberrant recruitment of translation regulators to the translation start site of mRNAs. In the proposed study, the team will interrogate how post-translational changes in FXR1 contribute to chemoresistance by abrogating tumor suppressive mechanisms in cancer cells. This will be an important mechanism because FXR1 is highly expressed in a broad range of cancers, such as lung, cervical, esophageal cancer, and ovarian cancer. Thus, the results obtained from this proposal could be developed as a druggable survival mechanism for treating various cancers.
