17 Jan Dr. Pradeep Chaluvally-Raghavan awarded NIH R01 grant
Pradeep Chaluvally-Raghavan, PhD has been awarded a National Institute of Health (NIH) Research Project Grant (R01) on “Role of RNA activation in Tumor Progression and Metastasis”.
The objective of this grant is to characterize the underlying mechanism enabled by miR551b-mediated transcriptional activation defined RNA activation (RNAa) for signaling addictions in ovarian cancer. Our results suggest that the interaction of miRNA on the promoters leads to conformational changes in the promoters, that improves the occupancy of transcription factors (TFs) and RNA-Polymerase-II (RNA-Pol-II) on promoter of genes for transcription of oncogenes like STAT3. We expect that our studies will establish new paradigms for disrupting signaling addictions in tumor cells, to inhibit progression and metastasis of ovarian cancer. miR551b is also amplified in breast, lung and cervical cancers. Thus, we believe, our results will have a broader impact on other cancers, which encompass miR551b amplification.