Dr. Anna Palatnik awarded CTSI Traditional Pilot Grant on Racial Disparities in Preeclampsia

Dr. Anna Palatnik awarded CTSI Traditional Pilot Grant on Racial Disparities in Preeclampsia

Anna Palatnik, MD, assistant professor of obstetrics and gynecology (maternal fetal medicine), has been awarded a CTSI grant to investigate “Racial differences in DNA-methylation profiling of human placentas in pregnancies complicated by preeclampsia”.

Racial disparities in preeclampsia are well established, with non-Hispanic black women having a greater risk of developing preeclampsia compared with women from other racial and ethnic groups. In addition, non-Hispanic black women often have more severe and early-onset disease and are at a greater risk for severe complications secondary to preeclampsia. Epigenetic features have been implicated in the pathogenesis of preeclampsia. However, studies have not

investigated whether epigenetic modifications can explain racial disparity seen with preeclampsia. In this study, Dr. Palatnik, in collaboration with Dr. Huang as a Co-Investigator, propose an innovative idea of exploring the causes behind racial disparity in preeclampsia through a comprehensive assessment of DNA methylation profiling in human placentas of pregnancies complicated by preeclampsia. This study will help to understand molecular mechanisms behind racial disparity seen with preeclampsia.