Jennifer McIntosh, DO – Novel Role for Placental Endothelial Mitochondria in Preeclampsia

Jennifer McIntosh, DO – Novel Role for Placental Endothelial Mitochondria in Preeclampsia

When:
May 15, 2019 @ 12:00 pm – 1:00 pm
2019-05-15T12:00:00-05:00
2019-05-15T13:00:00-05:00
Where:
Ob-Gyn Conference Room #252 (2nd floor Wisconsin Diagnostic Lab Building)
Contact:
Taylor Anglin
(414) 805-5695
WHEN: May 15, 2019 @ 12:00 pm – 1:00 pm

Presented by

Jennifer McIntosh, DO, MS
Assistant Professor, Department of Obstetrics & Gynecology, Division of Maternal-Fetal Medicine
Medical College of Wisconsin

Dr. McIntosh’s Research

Maternal and neonatal morbidity and mortality caused by preeclampsia is a significant global health burden with approximately 10 million pregnancies impacted resulting in nearly half a million fetal or neonatal lives lost each year. A novel relationship may exist between mitochondrial damage and endothelial dysfunction and subsequent development of preeclampsia.

Our overall goal is to investigate the mechanism whereby placental hypoxia is responsible for release of ROS and inflammation secondary to mitochondrial DNA (mtDNA) and if there is altered FMD as a result of heightened mtDNA in vessels from placentas in those with preeclampsia.

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