Dr. Pradeep Chaluvally-Raghavan awarded American Cancer Society - Cancer Center Seed Grant on Unexpected Roles of microRNAs on Transcriptional Activation

Dr. Pradeep Chaluvally-Raghavan awarded American Cancer Society – Cancer Center Seed Grant on Unexpected Roles of microRNAs on Transcriptional Activation

Pradeep Chaluvally-Raghavan, PhD has been awarded an American Cancer Society – Cancer Center Seed Grant on “RNA Activation Driven Ovarian Cancer grant on Unexpected roles of microRNAs on transcriptional activation”.

In this study, we are uncovering unconventional actions of microRNAs such as RNA activation. Our data demonstrate that tumor cells rely on RNA activation for rapid induction of oncogenes for signaling addiction. We have shown that miR551b bind on the promotors of oncogenes and upregulate their transcription by facilitating the recruitment of RNA-Polymerase-II and transcription factors. We hypothesize that the rapid induction of oncogenes by RNA activation modulate autocrine signaling required for oncogenic addictions that make the tumor cells self-sufficient for growth and metastasis.

Dr. Pradeep Chaluvally-Raghavan received his PhD degree in 2006 from the University of Calicut, India where he focused on the role NF-kappa B activation and pro-inflammatory cytokine genes in melanoma models. After completion of graduate school, he moved to the laboratory of Dr. Yosef Yarden at the Weizmann Institute of Sciences, Israel for postdoctoral research. In Dr. Yarden’s laboratory, he studied the role of epidermal growth factor receptor (EGFR) family members in breast cancer progression. In 2016, he was recruited as a tenure track Assistant Professor to the Department of Obstetrics and Gynecology at the Medical College of Wisconsin. In the current position Dr. Chaluvally continues his post-doctoral work initiated in the Mills lab, and extends this research into other areas of non-coding RNA biology. Specifically, he is studying the role of non-coding RNA in mediating transcriptional and post-transcriptional regulation of gene expression. Over the last 6 years, he has made major scientific contributions to our understanding of the role of non-coding RNA aberrations as part of the CNVs in cancer.

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