Calendar of Events

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Featuring The Roland S. Cron Lectureship

Guest Speaker

Kristyn Melíssa Brandi, MD, MPH
Board Chair
Physicians for Reproductive Health

About Dr. Brandi

Dr. Kristyn Brandi (pronouns: she/her/ella) is an Assistant Professor at Rutgers – New Jersey Medical School, where she completed her medical school and residency. She completed a Family Planning Fellowship at Boston University where she also earned her Master’s in Public Health with a concentration in Health Law, Bioethics and Human Rights. Her research is on reproductive decision making, contraceptive coercion, and racism in reproductive health care. She serves as the Board Chair of Physicians for Reproductive Health, sits on several sub-committees for the Society of Family Planning and is a founding member of Centering Equity, Racial and Cultural Literacy in Family Planning (CERCL-FP). She proudly identifies as a Latina pansexual abortion provider.

Agenda

Time	Activity
7:15am	GRAB AND GO BREAKFAST
7:45am	WELCOME & INTRODUCTIONS
8:00am	Christine Livergood, MD, MFM Fellow Characterization of RhoBTB1, a PPARγ target gene, in the Placenta Mentors: Curt Sigmund, PhD & Jenn McIntosh, MD
8:15am	Jordan Hauck, DO, R3 Risk of unplanned healthcare utilization in post-partum period for patients with hypertensive disorders of pregnancy Mentor: Anna Palatnik, MD
8:30am	Leigh Mahlum, MD, R3 Factors associated with persistent hypertension at 1-year postpartum in patients with gestational hypertension or preeclampsia Mentor: Anna Palatnik, MD
8:45am	Sarah Amherdt, MD, R3 Incidence of adverse pregnancy outcomes based on the degree of short interpregnancy interval in urban Milwaukee population Mentor: Anna Palatnik, MD
9:00am	Zack Schoppen, MD, R3 What To Expect When You’re Expecting a Medical Student Mentor: Kate Dielentheis, MD
9:15am	Steph Nguyen, MD, R3 Continuity of Care and Non-Urgent Health Care Utilization Mentors: Jessica Francis, MD & Stephen McAvoy, MD
9:30am	BREAK
9:45am	Alex Petrie, MD, R3 Evaluating the use and utility of a Weight Loss Clinic referral after surgical treatment of Endometrial Cancer Mentor: Erin Bishop, MD
10:00am	Katie Pellino, MD, R3 Post-Discharge Opioid Prescribing After Cesarean: A Quality Improvement Initiative Mentor: Erika Peterson, MD
10:15am	David Eggert, DO, R2 The Influence of Patient Education Level, Infertility Treatment, and Pregnancy and Breastfeeding Status on Perceptions of the COVID-19 Vaccine: A Mixed Methods Study Mentor: Stephanie Gunderson, MD
10:30am	Rebecca Sigourney, MD, R2 Investigating the Impact of the Addition of a MIGS Surgeon on Surgical Volume of General OBGYNs Mentor: Ben Beran, MD
10:45am	BREAK
11:00am	The Roland S. Cron Lecture: Kristyn Melíssa Brandi, MD, MPH Title: "Who is in Control Here- Contraceptive Coercion and Reproductive Justice"

Learn More about Resident and Fellow Research & Alumni Day

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Presented by

Hallgeir Rui, MD, PhD
WBCS Endowed Professor of Breast Cancer Research
Vice Chair of Research, Department of Pathology
Director of MCW Tissue Bank
Associate Director of Shared Resources, MCW Cancer Center
Medical College of Wisconsin

About

Hallgeir Rui, MD, PhD is internationally recognized for his research on hormone signaling in breast cancer, and has a strong track record of leadership, mentoring and collaboration. He is the WBCS Endowed Professor of Breast Cancer Research at the Medical College of Wisconsin (MCW), with his primary appointment in the Department of Pathology, and a secondary appointment to the Department of Pharmacology & Toxicology. In addition, Dr. Rui serves as the Associate Director of Basic Science and Shared Resources at the MCW Cancer Center. With his past experience as a Program Leader and Shared Resource Director at the NCI-designated Sidney Kimmel Cancer Center at Thomas Jefferson University, Dr. Rui brings valuable experience to the MCW Cancer Center efforts toward NCI-designation. Dr. Rui serves on the Breast Cancer Translational Research Committee of NRG Oncology.

A central focus of hisresearch is on molecular profiling of solid tumors, with published track record in malignancies of the breast, pancreas, prostate, colon, head and neck and melanomas. Key areas of interest are therapy-relevant protein expression, including pathway-activation status and tumor immunology-related markers, with development of better predictive markers and improved personalized cancer care as the overarching goal. Efforts are dedicated to improving methods and applications for quantitative, multiplex immunohistochemistry (IHC) for single-cell protein marker analyses – histocytometry – in solid tumors.

His laboratory invented novel ultrahigh density tissue arraying technology termed cutting-edge matrix assembly (CEMA) that overcomes limitations of core-based tissue arrays (US patent 8,349,584). Our laboratory, in collaboration with Dr. Kay-Uwe Wagner, developed novel prolactin-humanized NSG-Pro mouse strain for more accurate modeling and drug response testing of human breast cancer and other prolactin receptor-positive cancers, and my team has established a panel of new patient-derived breast cancer xenograft models in NSG-Pro mice.

Dr. Rui has extensive experience in facilitating multidisciplinary and collaborative program projects, including a concluded $6.7 million Promise Project Award funded by Susan G. Komen Foundation. Attesting to the productive use of immunofluorescence-based quantitative histocytometry and tissue arraying technologies for high-throughput application of innovative and nonstandard technologies for immunoprofiling of solid tumors, I led a multidisciplinary team that quantified levels of more than 100 therapy-relevant protein markers in nearly 3,000 breast cancer specimens, using tissue arrays and accompanying clinical data assembled and procured by a consortium of five institutions. As the leader of this consortium, I coordinated extensive efforts to combine tissue resources, data, equipment resources and broad areas of expertise.

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The Annual Women’s Health Conference is a one-day CME accredited program through MCW, ACOG and AAFP, providing up-to-date information in all aspects of Women’s Health and medical updates in General OBGYN and subspecialties. While most conferences focus on the needs of our patients, we have taken an active approach to incorporate provider wellness. In recent years, we have featured topics such as provider burnout, self-care, and second victim. Some of our most popular topics have included contraception, sexual dysfunction and menopause.

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Guest Speaker – Lauren Streicher, MD:

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Clinical Professor of Obstetrics & Gynecology at Northwestern Medicine
Medical Director – Northwestern Medicine Center for Sexual Medicine and Menopause

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Educates women through consumer publications, media appearances, and writing books, such as:

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Speakers and Topics:

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• Olushola (Shola) Akinshemoyin Vaughn, MD – Vulvar dermatoses
• Lauren F. Streicher, MD – Sex RX: Overview of female sexual dysfunction and sexual health – bringing a taboo topic into the office
• Amanda Kong, MD and Adrienne Cobb, MD – Common breast complaints and care for women in a general practice
• Emily Davidson, MD – Evaluation of urinary symptoms including urinary incontinence and overactive bladder
• Wendi Ehrman, MD and Angela Rabbitt, DO – Identification and treatment of sexually exploited young women
• Jessica A Smith, MD and Kendra Eaves, CGC – Prenatal genetic testing
• Chris Smith, MDiv, LMFT – Mindfulness Based Stress Reduction
• Jayme Bosler, MD – Evaluating infertility

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Learn more about the conference

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Presented by

Victor Jin, PhD
Linda T. and John A. Mellowes Endowed Chair of Bioinformatics and Data Analytics
Director, Bioinformatics Shared Resources
Professor, Institute for Health and Equity/Biostatistics
Medical College of Wisconsin

About

Dr. Jin has extensive experience in developing computational and genomics approaches for analyzing various omics-seq data, and runs a systems biology lab with a balanced dry and wet components.

Research Interests:

1) Developing genomics and computational approaches for the identification of three-dimensional (3D) chromatin interactions from the various omics-seq data.
2) Functionally and mechanistically characterizing the roles of epigenetic marks in cancer development and progression using novel techniques such as 3C/ChIP/RT-qPCR, 3D-FISH and CRISPR/Cas9.
3) Adapting/applying genome-wide omics-seq techniques in patient tissues to identify epigenetic-driven therapeutic targets and biomarkers.

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Schedule:

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Time	Activity
7:15am	BREAKFAST
7:45am	WELCOME & INTRODUCTIONS
8:00am	Yiwen Cui, MD, MFM Fellow O-GlcNAc transferase contributes to sex-specific placental deregulation in gestational diabetes Mentor: Stephanie Olivier-Van Stichelen, PhD
8:15am	Lindsay McAlarnen, MD GYN ONC Fellow Exosomal FXR1 as a translational mediator in the ovarian cancer microenvironment Mentor:Pradeep Chaluvally-Raghavan, PhD
8:30am	Rebekah Summey, MD GYN ONC Fellow Exploration and exploitation of hormonal pathways in adult granulosa cell tumors for development of targeted therapeutics Mentors: Elizabeth Hopp, MD and Janet S. Rader, MD
8:45am	Alex Levy, MD, R4 Is One Superior? Comparison of Early Removal Rates of Intrauterine Device versus Nexplanon Subdermal Implant in Women Ages 16-24 in Milwaukee, Wisconsin Mentor: Jessica Francis, MD
9:00am	Rana Aliani, MD R3 Impact of Race, Insurance, and Procedural Timing on Sterilization Method Mentor: Ben Beran, MD
9:15am	Mary Siracusa, MD R3 Determining Patients’ Preferred Ultrasound Provider During the Preoperative Evaluation of Endometriosis Mentor: Ben Beran, MD
9:30am	BREAK
9:45am	Iman Khan, MD R3 Postpartum Care in a Post-COVID Era Mentors: Amy Domeyer, MD and Erika Peterson, MD
10:00am	Blake Neuburg, MD R3 Inpatient Versus Outpatient Management of Gestational Hypertension or Preeclampsia Without Severe Features Mentor: Anna Palatnik, MD
10:15am	Ankita Sarawagi, MD R3 Screening rates for intimate partner violence (IPV) in the OBGYN clinic from 2019 to 2022 Mentor: Kim Gecsi, MD
10:30am	Margaret Bruce, MD R3 Evaluating Modern Contraceptive Methods as Risk Factors for Recurrent UTI’s Mentor: Sumana Koduri, MD
10:45am	BREAK
11:00am	The Roland S. Cron Lecture: Nandini Raghuraman, MD, MS Fellowship Program Director, Maternal-Fetal Medicine Assistant Professor, OB/GYN Washington University School of Medicine "Moving Evidence into Clinical Practice on Labor & Delivery"
12:00pm	Questions for Dr. Raghuraman
12:30pm	Lunch

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Presented by

Wei Xu, PhD
Professor of Oncology, Marian A. Messerschmidt
Associate Director,, McArdle Laboratory for Cancer Research
Director of MCW Tissue Bank
Co-Director, Genetic and Epigenetic Mechanism Program, Carbone Cancer Center

About

Dr. Xu’s laboratory explores the protective roles of environmental and nutritional estrogenic compounds in mammals for breast cancer prevention and treatment. Estrogen receptors (ERs) exist in two forms, ERa and ERb, which have opposing roles in cell proliferation. Estrogenic compounds can control balance between mammary cell proliferation and differentiation via stimulating the formation of different forms of ER dimers. Xu lab has developed the Bioluminescent Resonance Energy Transfer (BRET) assays for detecting in vivo homodimerization and heterodimerization of ERa and ERb induced by estrogenic compounds. Biological functions of these estrogenic compounds are currently being investigated in cell-based and breast cancer mouse models. Dr. Xu’s laboratory has also employed biochemical and functional genomic approaches, as well as mouse genetics to decipher the contribution of histone arginine methylation to the epigenetic control of cancer cells. The major focus of Xu lab is on a protein arginine (R) methyltransferase CARM1/PRMT4, a nuclear hormone receptor co-activator. Dr. Xu has identified a number of non-histone substrates for CARM1 and is in the progress of elucidating the functions of protein arginine methylation in breast cancer initiation and progression.

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