Calendar of Events
Zigang Dong, MD, DPH
Keynote Speaker
Research Day, which will be held on Wednesday, September 18, 2013 in association with the Convocation, will be an excellent opportunity for all scientists and clinicians at MCW and its affiliated institutions to showcase their basic, clinical, population health, and translational research and to identify new possibilities of collaboration. Here are some highlights for the MCW Research Day Poster Session.
Agenda
| 9:00am - 8:00pm | Abstract Posters Available for Viewing |
| 11:00am - 12:00pm | ODD Numbered Abstract Poster Presentations |
| 12:00 - 1:00pm | MCW Research Day Keynote Lecture “Chemoprevention as an Approach to Cancer Prevention” Zigang Dong, M.D., D.P.H. Executive Director McKnight Presidential Professor in Cancer Prevention Hormel-Knowlton Professor Cellular and Molecular Biology The Hormel Institute University of Minnesota – Mayo Clinic |
| 1:00pm - 2:00pm | EVEN Numbered Abstract Poster Presentations & Award Selections |
| 4:30pm - 6:00pm | Convocation |
Clinical fellows, residents and junior faculty up to the level of Assistant Professor at MCW are strongly encouraged to submit abstracts for presentation in the poster session. All forms of medical research are invited (basic, clinical/translational, health policy, outcomes, population health, etc.) Senior faculty and research support staff are invited to submit abstracts for the poster session and/or the abstract booklet, but will not be eligible for awards.
Any abstracts and posters on studies that have not been published in full manuscript prior to the abstract submission date can be presented on the Research Day. That includes abstracts and posters that have not been presented previously and those that have been presented previously at regional, national, or international conferences.
View the Flyer
Presented by
Qing Robert Miao, PhD
Qing Robert Miao, PhD
Associate Professor
Medical College of Wisconsin
Pediatric Surgery and Pediatric Pathology
About Dr. Miao
Dr. Miao’s current research has been focused on the molecular mechanisms of a new ligand-receptor pair, Nogo-B and Nogo-B receptor (NgBR), in regulating endothelial cell migration and blood vessel formation during embryo development and tumor growth. In addition, his team is establishing in vitro and in vivo models to dissect the molecular mechanisms of endothelial cells interacting with microenvironment niche during vasculogenesis and angiogenesis, and developing therapeutic approaches to modulate Nogo-B/NgBR functions.
Presented by
Associate Professor
Marquette University
Exercise Science Program
Department of Physical Therapy
Associate Professor
Medical College of Wisconsin
Department of Physical Medicine and Rehabilitation
About Dr. Hunter
Sandra Hunter, PhD
Dr. Hunter’s current research areas:
- The impact of stress on neuromuscular function and muscle fatigue
- The neural control of muscle fatigue and task failure with age
- Sex and task differences in muscle fatigue of young and older adults
- Adaptations of neuromuscular aging: control of muscle force and motor unit variability
About Dr. Eickmeyer
Sarah Eickmeyer, MD
Dr. Eickmeyer’s specialties include Amputee/Prosthetic Rehabilitation, Musculoskeletal, Cancer Rehabilitation, Women’s Health Rehabilitation
Presented by
Rashmi Sood, PhD
Rashmi Sood, PhD
Assistant Professor
Medical College of Wisconsin
Pathology
About Dr. Sood
Dr. Rashmi Sood received her PhD in Molecular Biology from the Tata Institute of Fundamental Research, University of Bombay, India. Her postdoctoral studies were conducted at the Blood Research Institute, Blood Center of Wisconsin, Milwaukee, where she specialized in coagulation and vascular biology. Dr. Sood’s laboratory develops and utilizes rodent models of placental disease and pregnancy disorder to understand disease mechanisms. In parallel, her laboratory seeks to discover predictive biomarkers that can be used to identify high-risk pregnancies in women.
Presented by
Carol L. Williams, PhD
Carol L. Williams, PhD
Professor
Medical College of Wisconsin
Department of Pharmacology and Toxicology
About Dr. Williams
Dr. Williams received a Champion in Women’s Health Award from the Wisconsin Women’s Health Foundation in May, 2013. Her research focuses on the biochemical signaling pathways and cellular processes regulated by the Ras and Rho families of small GTPases. These proteins regulate important physiological processes in a variety of cell types, including contraction of smooth muscle cells and proliferation of epithelial cells. Abnormal signaling by these proteins may contribute to several diseases, including asthma, hypertension, atherosclerosis, and cancer. The importance of these proteins in human health provides the driving force for our studies.
Presented by
Srividya Kidambi, MD
Srividya Kidambi, MD
Assistant Professor of Medicine
Associate Fellowship Program Director
Medical College of Wisconsin
Department of Medicine
Division of Endocrinology, Metabolism, and Clinical Nutrition
About Dr. Kidambi
Dr. Kidambi’s current research involves Association of aldosterone with metabolic syndrome and insulin resistance, and Gender and ethnic differences in the body fat distribution and its role in causing diseases such as heart disease or high blood pressure. She has authored several papers in medical journals on these topics.
Presented by
Magdalena Chrzanowska-Wodnicka, PhD
Magdalena Chrzanowska-Wodnicka, PhD
Associate Investigator, BloodCenter of Wisconsin
Assistant Adjunct Professor Pharmacology and Toxicology, Medical College of Wisconsin
About Dr. Chrzanowska-Wodnicka
Dr. Chrzanowska-Wodnicka’s laboratory studies the function of small G proteins in the cardiovascular system. We use transgenic mouse and zebrafish models for in vivo studies and a variety of biochemical, molecular and microscopy approaches to interrogate signaling by small GTPases in vascular cells ex vivo.
Small G protein Rap1 has been the main focus of research in my laboratory over the past few years. Rap1, evolutionarily conserved and ubiquitously expressed, is activated downstream from multiple cell surface receptors and regulates several basic cellular functions: adhesion, migration, polarity, differentiation and growth. Well studied in vitro, Rap1 functions in mammalian systems in vivo are still not very well understood.
Presented by
Tina W. F. Yen, MD, MS
Tina W. F. Yen, MD, MS
Associate Professor
Medical College of Wisconsin
Department of Surgery
About Dr. Yen
Dr. Yen’s current research focuses on studying breast cancer quality of care, patterns of care, and the relationship of these patterns of care to outcomes of care through the analysis of administrative data, Medicare claims, and tumor registry data. Current projects include studying lymphedema incidence and risk factors among older breast cancer women (funded by a Career Development Award by the National Institutes of Health) and hormone therapy use in older breast cancer women.
Presented by
Paula Traktman, PhD
Paula Traktman, PhD
Walter Schroeder Professor and Chairman
Medical College of Wisconsin
Microbiology and Molecular Genetics
About Dr. Traktman
Dr. Traktman’s research focus is in vaccinia virus: replication, morphogenesis, and the role of dynamic phosphorylation. VRK protein kinases: the role of the cellular VRKs in cell structure, function and proliferation.
Presented by
Amit Joshi, PhD
Amit Joshi, PhD
Associate Professor
Medical College of Wisconsin
Department of Radiology
About Dr. Joshi
The overarching goal of my research is to develop technologies for image guided interventions in cancer. During my doctoral training, I studied near-infrared (NIR) light interaction with biological tissue and developed mathematical algorithms and imaging methods for investigating fluorescent structures with NIR light in deep tissue. I was the first researcher to propose fully adaptive 3D image reconstruction algorithms in fluorescence optical tomography, which allowed the investigation of liter scale tissue volumes at mm resolution with computationally tractable methods. During my doctoral and postdoctoral training, I also collaborated with nuclear energy researchers from Los Alamos National Labs for porting subatomic particle transport simulation methods for modeling near infrared photon transport in tissue, with first principle derived deterministic methods, independent of assumptions on tissue optical properties, and sourcedetector configurations. The work resulted in successful NIH STTR phase I and Phase-II applications for developing optical photon transport modeling software, under my leadership as the consortium PI at Baylor College of Medicine.
Read More about Dr. Joshi
Presented by
Christopher R. Chitambar, MD
Christopher R. Chitambar, MD
Professor of Medicine
Director, Hematology/Oncology Fellowship Program
Division of Hematology & Oncology
Medical College of Wisconsin and Froedtert Clinical Cancer Center
About Dr. Chitambar
Dr. Chitambar’s research focuses on understanding the role of iron proteins in tumor cell growth, apoptosis, oxidative stress, and mitochondrial function, with a particular emphasis on the development of novel gallium compounds as therapeutic agents. His clinical emphasis is on the treatment of patients with breast cancer and lymphoma and the development of clinical trials for these diseases.
Long acting reversible contraception (LARC) has been shown to be an effective pregnancy prevention strategy for women’s health in other communities. Could greater LARC utilization lead to better health outcomes for women and children in Milwaukee?
Join health practitioners and diverse stakeholders in women and children’s health to further our collective understanding of the science, learn about successful models of LARC implementation in other communities, and explore the best strategies for Milwaukee.
Panelists Include
Renaisa Anthony, MD, MPH
Assistant Professor Department of Health Promotion and Social and Behavioral Health
University of Nebraska Medical Center, College of Public Health
Kathy King, MD
Medical Director, Planned Parenthood of Wisconsin
Assistant Professor, Department of OBGYN, Medical College of Wisconsin
Presented by
Cheryl Stucky, PhD
Professor of Cell Biology, Neurobiology & Anatomy
Director, Neuroscience Doctoral Program
Medical College of Wisconsin
About Dr. Stucky
In virtually all of our daily activities, we rely on our skin and nervous system to interact with the world around us. Our laboratory is keenly interested in how our skin sensory neurons detect environmental stimuli, such as tactile pressure, cold and heat, and painful stimuli. The best candidate proteins for transduction of physical stimuli are members of the Transient Receptor Potential ion channel family. For example, we recently showed that the Transient Receptor Potential Melastatin 8 (TRPM8), the receptor activated by menthol and peppermint, is a key receptor that detects cool and painfully cold stimuli (Bautista et al., 2007, Nature).
The purpose of the Action Learning Collaborative (ALC) is to accelerate collaboration among interested colleagues across organizations, sectors, disciplines, and perspectives to address challenges to greater use of LARC in our community as an effective prevention strategy for women’s health.
The ALC is made up of small teams of colleagues who agree to work together, with support and assistance from PCI Staff over 2 – 3 months. Together teams have the capacity to suggest recommendations for overcoming leading barriers identified by diverse stakeholders at the June 2015 PCI Action Learning Workshop. Individuals are encouraged to register, indicating one, two, and/or three themes they would like to pursue further. The PCI staff will facilitate opportunities for groups to form and participate in ‘barrier busting’ strategies.
Registration due by Friday, September 11.
The purpose of the Action Learning Collaborative (ALC) is to accelerate collaboration among interested colleagues across organizations, sectors, disciplines, and perspectives to address challenges to greater use of LARC in our community as an effective prevention strategy for women’s health.
The ALC is made up of small teams of colleagues who agree to work together, with support and assistance from PCI Staff over 2 – 3 months. Together teams have the capacity to suggest recommendations for overcoming leading barriers identified by diverse stakeholders at the June 2015 PCI Action Learning Workshop. Individuals are encouraged to register, indicating one, two, and/or three themes they would like to pursue further. The PCI staff will facilitate opportunities for groups to form and participate in ‘barrier busting’ strategies.
Readiness Session Registration due by Friday, September 11.
Presented by
Ling Wang, PhD
Ling Wang, MD, PhD
Instructor
Department of Obstetrics & Gynecology
Medical College of Wisconsin
About Dr. Wang
Dr. Wang’s. has extensive experience in tumor angiogenesis and tumor biology. Her long-term research interests involve the development of a comprehensive understanding of the molecular mechanisms and the molecule-based diagnosis and therapy to woman cancer. Her study in neuropilin biology determines the status of neuropilin-1/GIPC (RGS-GAIP-interacting protein) signaling in vascular development and tumor progression. Currently, she is focused on to identify the role of microenvironment and germline BRCA1 mutation in breast cancer and ovarian cancer metastases, with specific emphasis on the signaling mechanisms and clinical significance.
Presented by
Weiguo Cui, PhD
Weiguo Cui, PhD
Associate Investigator
Blood Research Institute
BloodCenter of Wisconsin
Assistant Professor
Department of Microbiology and Molecular Genetics
Medical College of Wisconsin
About Dr. Cui
During an acute viral or bacterial infection, naïve T cells can differentiate into multiple types of effector and memory T cells that help to mediate pathogen clearance and provide long-term protective immunity. The main goal of our research in the lab is to elucidate how TCR and cytokine signaling and their downstream transcriptional programs regulate pathogen-specific T cells to proliferate, differentiate into either short-lived effector cells or long-lived memory cells.
Gloria Halverson, MD OBGYN Professor Emeritus
Dr. Gloria Halverson, former OBGYN physician, will be presenting at MCW’s Global Health Week.
MCW Global Health Week is an opportunity to co-promote the diverse communities our faculty, staff, and partners are serving to advance health. We anticipate that together, we can continue to share credible, collaborative, and mutually beneficial efforts in global health from neighborhoods to nations.
All events are co-sponsored by MCW departments, offices and centers. Topic areas intentionally cross all of our missions of clinical care, research, education and community engagement.
Presented by
Sandra Hunter, PhD and Meredith Cruz, MD, MBA/MPH
About Dr. Hunter
Sandra Hunter, PhD
Dr. Hunter’s current research areas:
- The impact of stress on neuromuscular function and muscle fatigue
- The neural control of muscle fatigue and task failure with age
- Sex and task differences in muscle fatigue of young and older adults
- Adaptations of neuromuscular aging: control of muscle force and motor unit variability
About Dr. Cruz
Meredith Cruz, MD, MBA/MPH
Dr. Cruz specializes in Maternal Fetal Medicine with an emphasis on critical care and high risk obstetrics, prenatal diagnosis, and ultrasonography. Her other areas of expertise include hypertension, diabetes, and cardiac issues in pregnancy.
Presented by
Allison D. Ebert, PhD
Assistant Professor
Department of Cell Biology, Neurobiology and Anatomy
Medical College of Wisconsin
About Dr. Ebert
Dr. Ebert’s research interests are in the area of neurodegenerative diseases, both understanding the molecular basis for the disease progression and finding effective experimental therapies. My current research focuses on using induced pluripotent stem cells (iPSCs) derived from patient tissue to understand disease mechanisms and therapeutic intervention. Specifically, my lab is investigating the cell death processes involved in motor neuron loss in spinal muscular atrophy (SMA). We are using iPSCs derived from an SMA patient to generate motor neurons, astrocytes, and muscle cells to determine how the motor neurons are dying and whether the astrocytes and muscle cells are contributing to the disease process. My lab is also testing the therapeutic potential of ex vivo gene therapy in animal models of Parkinson’s and Huntington’s diseases by transplanting neural stem cells engineered to produce specific growth factors known to aid neuron survival. The growth factors I am actively examining are glial cell line-derivedneurotrophic factor (GDNF), insulin like growth factor (IGF-1), brain derived neurotrophic factor (BDNF), and vascular endothelial growth factor (VEGF). Finally, we are interested in characterizing and understanding survival, migration, and differentiation patterns of transplanted stem cells in models of disease, which could have important clinical relevance.
This talk will detail what constitutes a significant family history along with discussion of genetic testing. The talk will also touch on management of hereditary cancer syndromes, such as Lynch syndrome and BRCA.
Presentation by: Elizabeth Hopp, MD, Gynecologic Oncologist
Register Online
Register online through the link to Froedtert’s classes and events below.
Presented by
Michael Flister, PhD
Associate Professor
Department of Physiology
Medical College of Wisconsin
Specialization and Research Interests
Genetics and Genomics; Molecular and Cellular Physiology.
Presented by
Bryon Johnson, PhD
Bryon Johnson, PhD
Professor
Department of Pediatrics (Hematology and Oncology, BMT)
Microbiology and Molecular Genetics
Medical College of Wisconsin
About Dr. Johnson
Dr. Johnson is interested in understanding the biology and immunology of cancer, and uncovering novel immune-based approaches to treat cancer. His current research focuses on combining the following approaches to improve the use of cancer immunotherapy for treating both solid tumors and hematologic cancers: (1) immune checkpoint protein blockade, (2) adoptive transfer of cancer-reactive T lymphocytes, and (3) the use of metabolic inhibitors to increase T cell immunity.
Hosted by the PCI: A Catalyst for Women’s Health
Last June, a pilot program of the Pabst Catalyst Initiative (PCI), co-led by the UWM Zilber School of Public Health, Medical College of Wisconsin Department of Obstetrics & Gynecology, and the City of Milwaukee Health Department, gathered more than 50 stakeholders for an action learning workshop to consider the latest science and best practices of Long Acting Reversible Contraception (LARC). Out of this meeting, three collaborative strategies have been pursued:
- Acceptability: better understanding community perspectives and concerns about LARC
- Availability: working with health providers to enable same-day LARC insertion when requested by women
- Accessibility: increasing access to LARC and women’s healthcare through mobile health services
“Action Learning Teams” open to all interested individuals and organizations have been exploring these strategies and are ready to share their work. Join us to hear strategic updates, provide feedback on recommendations, and work toward strategic alignment with related efforts for improving women’s health.
Learn more about Pabst Catalyst Initiative: A Catalyst for Women’s Health
Presented by
Carmen Bergom, MD, PhD
Carmen Bergom, MD, PhD
Assistant Professor
Department of Radiation Oncology
Medical College of Wisconsin
About Dr. Bergom
Dr. Ebert’s research interests are in the members of the Rho, Rac, Ras, and Rap families of small GTPases regulate cancer development and progression. In addition, Ras and other small GTPases can alter the sensitivity of cancer cells to radiation and chemotherapy. Identifying new ways to suppress small GTPase activation in cancers may provide new treatment approaches. While most small GTPases promote cancer and are oncogenic, a few of the small GTPase family members are actually tumor suppressors. Our laboratory studies members of the small GTPase family which have tumor suppressor activities.
The DIRAS family of small GTPases has the unique property of having tumor suppressive actions, rather than the tumor promoting actions common to most other small GTPases. DIRAS1 and DIRAS2 are poorly characterized thus far, with the literature consisting of only a few publications demonstrating tumor suppressor functions in central nervous system and esophageal malignancies. DIRAS3 (ARHI) is the most studied of the DIRAS proteins. DIRAS3 is downregulated or lost in 40-70% of ovarian and breast cancers. Overexpression of DIRAS1 inhibits Ras-mediated cellular transformation of NIH3T3 cells, and DIRAS3 dramatically inhibits cells growth of breast and ovarian cancer cells. Our laboratory is currently studying the roles of DIRAS signaling in breast cancer and other malignancies.
Our long-term goal is to understand how small GTPases can be manipulated to enhance cancer treatment. The knowledge obtained from our studies may help define novel signaling pathways that modulate the functions of pro-oncogenic small GTPases in the Ras family. We hypothesize that knowledge of DIRAS family tumor suppressive signaling can identify new targets for cancer therapeutics and help to identify novel ways in which to abolish pro-oncogenic small GTPase signaling which is critical in the development and progression of a number of malignancies.
Breastfeeding education and promotion have been identified as vital components of improving the rate of breastfeeding initiation and continuation. Thanks to a generous donation by Mr. Paul and Dr. Kathy Kartke, this symposium will initiate a formal educational program for healthcare providers and staff.
Space is limited for onsite attendance, so it will be first come first served. RSVP to Kelly Winum at kwinum@mcw.edu with your name and credentials.
Videoconferencing will be available for those who are not able to attend and/or if space is full.
| Time | Topic |
|---|---|
| 8:00 AM | Registration and Breakfast |
| 8:10 AM | Welcome |
| 8:15 - 11:00 AM | Invited Expert Presentations and Panel Discussion |
Presented by
Lauren Elyse Hanley, MD, FACOG, IBCLC
Dr. Hanley is an Obstetrician/Gynecologist and Breastfeeding Medicine Specialist at the Massachusetts General Hospital in Boston, Massachusetts. She is an Assistant Professor of Obstetrics, Gynecology and Reproductive Biology at Harvard Medical School. She currently serves as the Chair and a founding member of the Expert Working Group in Breastfeeding of the American Congress of Obstetricians and Gynecologists. She also serves on the Executive Board of the Massachusetts Breastfeeding Coalition.
Jenny Thomas, MD, IBCLC
Dr. Jenny Thomas is a pediatrician and breastfeeding medicine specialist at Aurora Healthcare in Franklin, Wisconsin and is a Clinical Assistant Professor of Community and Family Medicine and Pediatrics at the Medical College of Wisconsin (MCW). She received her MD from MCW in 1993, and her MPH in 2011. She has been an International Board Certified Lactation Consultant (IBCLC) since 2003. She is now serving on the American Academy of Pediatrics (AAP) Section on Breastfeeding Executive Board after spending several years as the Chief of the Chapter Breastfeeding Coordinators. She also serves on the Executive Board of the Wisconsin Chapter of the AAP, and is a founder and the immediate-past Chairperson of the Wisconsin Breastfeeding Coalition. She is the author of “Dr. Jen’s Guide to Breastfeeding.”
Nancy Mohrbacher, IBCLC, FILCA
She is an internationally known lactation consultant, author, and breastfeeding smartphone app developer. Her books include “Breastfeeding Made Simple: Seven Natural Laws for Nursing Mothers”, “Working and Breastfeeding Made Simple”, and “Breastfeeding Solutions: Quick Tips for the Most Common Nursing Challenges”. In 2008 the International Lactation Consultant Association officially recognized Nancy’s contributions to the field of breastfeeding by awarding her the designation FILCA, Fellow of the International Lactation Consultant Association. Nancy was one of the first group of 16 to be recognized for their lifetime achievements in breastfeeding.
Accreditation
The Medical College of Wisconsin is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
The Medical College of Wisconsin designates this live activity for a maximum of 2.75 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
The Medical College of Wisconsin designates this activity for up to 2.75 hours of participation for continuing education for allied health professionals.
Presented by
Matt Scaglione, PhD
Matthew Scaglione, PhD
Assistant Professor
Department of Biochemistry
Medical College of Wisconsin
About Dr. Scaglione
K. Matthew Scaglione received his Bachelor of Science degree in Biology from McKendree University in 2001 and his Doctorate in Biochemistry from Saint Louis University School of Medicine in 2007 where his research focused on ubiquitin pathways in cancer. He performed postdoctoral studies at the University of Michigan School of Medicine from 2007 until 2013 investigating the role of protein quality control pathways in neurodegenerative diseases. During his postdoctoral studies Dr. Scaglione was awarded a F32 (Ruth L. Kirschstein National Research Service Award) and a NIH K99/R00 (Pathway to Independence Award). Dr. Scaglione joined the faculty of the Medical College of Wisconsin in 2013.
Protein aggregation is a hallmark of numerous neurodegenerative diseases including Alzheimer’s Disease, Parkinson’s Disease, Amyotrophic Lateral Sclerosis (ALS), and the polyglutamine diseases. Dr. Scaglione’s lab focuses on understanding how protein quality control pathways counteract protein aggregation to maintain neuronal health.
Presented by
Tamjid Chowdhury, PhD
Tamjid Chowdhury, PhD
Postdoctoral Fellow
Department of Obstetrics and Gynecology
Medical College of Wisconsin
Presented by
Pradeep Chaluvally-Raghavan, PhD
Assistant Professor
Department of Obstetrics and Gynecology
Medical College of Wisconsin
About Dr. Chaluvally-Raghavan
Dr. Pradeep Chaluvally-Raghavan received Ph.D. degree in 2006 from the University of Calicut, India where he focused on the role NF-kappa B activation and pro-inflammatory cytokine genes in melanoma models. After completion of graduate school, he moved to the laboratory of Dr. Yosef Yarden at the Weizmann Institute of Sciences, Israel for postdoctoral research. In Dr. Yarden’s laboratory, he studied the role of epidermal growth factor receptor (EGFR) family members in breast cancer progression.
Pradeep Chaluvally-Raghavan, PhD
During this period, he identified that NOTCH3 and NOTCH3-associated genes deregulate the growth of mammary epithelial cells and promote the transition of normal mammary duct to Ductal Carcinoma In Situ (DCIS) in breast cancer models. Further, during this transition phase of DCIS to invasive cancer, he characterized the role of three distinct pathways hypoxia, integrin and bone morphogenetic protein (BMP) signaling pathways. In 2010, he joined the lab of Dr. Gordon Mills in the Department of Systems Biology at the MD Anderson Cancer Center. In Mills lab, he focused on genomic aberrations such as gene mutation or copy number variation (CNVs), and its effect on downstream signaling pathways in breast and ovarian cancer. In 2016, he was recruited as a tenure track Assistant Professor to the Department of Obstetrics and Gynecology at the Medical College of Wisconsin. In the current position Dr. Chaluvally continues his post-doctoral work initiated in the Mills lab, and extends this research into other areas of non-coding RNA biology. Specifically, he is studying the role of non-coding RNA in mediating transcriptional and post-transcriptional regulation of gene expression. Over the last 6 years, he has made major scientific contributions to our understanding of the role of non-coding RNA aberrations as part of the CNVs in cancer.
Presented by
Stephanie Cossette, PhD
Post-doctoral Fellow
Department of Pediatrics-Neonatology
Medical College of Wisconsin
About Dr. Cossette
She is currently a Post-Doc Fellow in Dr. Ramani Ramchandran’s lab. She received the 2016 Edward J. Lennon, M.D. Award for an Outstanding Women Postdoctoral Researcher. Her research focuses on understanding the role of sucrose non-fermenting related kinase (SNRK) during cardiovascular development. SNRK is involved in the metabolism-sensing pathway and is regulated by liver kinase B1 (LKB1), which is a tumor suppressor that is also associated with the Peutz-Jeghers syndrome. By using the mammalian system to systematically remove SNRK from various types of tissue/organ populations, she will be able to investigate the specific role of SRNK in development as well as investigate the developmental relationship between SNRK and LKB1.
Presented by
Akiko Mammoto, MD, PhD
Assistant Professor
Department of Pediatrics
Medical College of Wisconsin
About Dr. Mammoto
Dr. Mammoto is an assistant professor in the department of Pediatrics. She is interested in cellular mechanotransduction in angiogenesis. Her recent research focuses on the role of angiogenesis in organ development and various pathological states. She has published more than 65 papers in high impact peer-reviewed journals such as Nature, Developmental Cell, Nature Communications, Journal of Biological Chemistry, etc.
Our Women’s Mental Health Psychologist Dr. Abbey Kruper, Education Curriculum & Instruction faculty Dr. Kristina Kaljo, and Obstetrician/Gynecologist Dr. Seema Menon are presenting their research poster at MCW’s Community Engagement Week 2017: Elevating Community Voices in Health.
Student-Centered Learning – Implementing a Sexual and Behavioral Health Curriculum with Adolescent Students
We have multiple faculty who will be presenting their research posters at MCW’s 2017 Innovations in Medical Education Conference.
- Kristina Kaljo PhD, Robert Treat, PhD, Lauren Hanley, MD and Cresta Jones, MD
Targeting the Needs of Multiple Providers: Measuring the Efficacy of a Breastfeeding Educational Symposium - Kristina Kaljo PhD, Matthew Tews, DO, Robert Treat, PhD
Expansive Horizons: Understanding the Experiences and Insights of Medical Students Participating in a New Distance Learning Environment
- Raj Narayan, MD, Kristina Kaljo, PhD, Rahmouna Farez, MD, Michael Lund, MD, Andrew Kastenmeier
Reinforcing Skills of the Novice Surgeon through Online Learning, Video Recording, and Self-Assessment - Amy Domeyer-Klenske, MD and Kristina Kaljo, PhD
Residents as Educators: Understanding the Role in Medical Student Education
Women in Science Series Features Highly Accomplished Local Researchers and Physicians
The Medical College of Wisconsin invites the public to attend the Women in Science (WIS) Series. Women in Science is an opportunity to meet outstanding female scientists and physicians and learn about their cutting-edge research.
The Women in Science Series is a membership program with five enlightening presentations, in lay language, designed to draw attention to scientific research projects at MCW as well as generate support for female scientists who serve as role models and mentors.
The successful WIS Series has been going strong since 2007.
Dr. Denise Uyar has been chosen by the Women in Science Advisory Committee for her recent research about HPV Vaccinations and Women’s Health.
Presented by
Denise Uyar, MD
Associate Professor
Department of Obstetrics and Gynecology
Medical College of Wisconsin
About Dr. Uyar
Dr. Denise Uyar joined the Department of Obstetrics and Gynecology in the Division of Gynecology Oncology at the Medical College of Wisconsin in October of 2004. She received her Doctor of Medicine from the University of Vermont in 1997. She subsequently went on to complete her residency in Obstetrics and Gynecology at the University of Vermont, Fletcher Allen Hospital in Burlington. After her four year residency, she continued her training in the subspecialty of Gynecology Oncology. Dr. Uyar completed a three year fellowship in Gynecology Oncology at The Cleveland Clinic.
Dr. Uyar’s clinical practice includes the care of women with gynecologic malignancies including uterine, cervical, ovarian primary peritoneal, fallopian tube, vulvar and vaginal malignancies and gestational trophoblastic disease. She performs the surgery, the post-operative therapy if indicated, and the follow up surveillance of women in her practice. In addition, she is also interested in the treatment of women who have been diagnosed with pelvic masses, pre-cancerous lesions of the cervix, vulva, vagina or uterus, as well as cancer screening and prevention. She is trained and has expertise in the administration of chemotherapy for gynecologic malignancies, including intraperitoneal chemotherapy for ovarian malignancy. She has extensive expertise in minimally invasive surgery including general laparoscopy and robotic assisted laparoscopy.
Presented by
Andreas M. Beyer, PhD
Andreas M. Beyer, PhD
Assistant Professor
Department of Medicine
Division of Cardiovascular Medicine
Medical College of Wisconsin
About Dr. Beyer
Andreas M. Beyer is an Assistant Professor in the Departments of Medicine and Physiology at the Medical College of Wisconsin. During his training in Genetics and Physiology, he has gained detailed expertise in generating and evaluating novel approaches in genetics, molecular biology and physiology. In his time spent in the lab he performs experimental troubleshooting involving video microscopy, fluorescent microvascular imaging, generation of genetic rodent models, physiological evaluation of in vivo vascular function and blood pressure. With the support of this research group and important local and national collaborators, Andreas is using live human tissues to address important questions in vascular biology that will lead to clinically relevant findings and drive further exploration of mechanism in rodent models. His lab hopes that clinically relevant data from human tissues will enable a detailed mechanistic understanding of disease that can then be used to develop novel therapeutics and translate both diagnostics and therapies themselves to the clinic.
The Beyer lab studies the complex relationship and physiological effects of vascular stress response with and aging. We are interested in how telomerase activity contributes to the regulation of reactive oxygen species (ROS) and nitric oxide (NO) in health and disease. The role of telomerase in aging and the development of cancer are well established. The catalytic subunit of telomerase, TERT, elongates telomeres in the nucleus to prevent cellular aging and promote proliferation. A potential role in the development of cardiovascular disease (CVD), especially via the endothelium where vascular disease begins, has not been described. This novel idea is supported by a recently described non-nuclear role for TERT in regulating levels of mitochondrial derived reactive oxygen species (mtROS) in fibroblasts. A similar function in endothelial cells would position TERT as a key regulator of oxidative stress and microvascular function.
Endothelial release of NO induces flow-mediated dilation (FMD) under physiological conditions and serves to prevent vascular smooth muscle proliferation and inflammation. In subjects with coronary artery disease (CAD), however, arteriolar FMD is mediated by mtROS, specifically hydrogen peroxide (H2O2), which is a pro-inflammatory and pro-atherosclerotic dilator. We observed that activation of telomerase restores nitric oxide (NO) as the mediator of FMD in vessels from subjects with CAD, while reduction of telomerase activity (TA) in vessels from subjects without CAD activates a CAD-like phenotype. We have generated novel decoy peptides that prevent either telomerase localization to the nucleus or translocation to the mitochondria. Inhibition of nuclear transport of TERT increases cytoplasmic (including mitochondrial) telomerase localization and activity. CAD is associated with elevations in Angiotensin II (ANG II) which contribute to elevated ROS and decreased NO-mediated endothelium-dependent dilation.
Our central hypothesis is that TERT plays a critical and previously undiscovered role in maintaining physiological NO levels while simultaneously suppressing the compensatory rise in mtROS during flow in coronary vessels of both mice and humans. Preliminary data indicate that acute stimulation of telomerase activity is sufficient to maintain NO release following vascular stress, and to decrease mtROS production, suggesting a role independent of telomere shortening. We are utilizing clinically-relevant stressors such as ANG II to deduce the role of mtTERT in relation to vascular stress responses and regulation of mtROS.
Ongoing studies integrate cell culture, in vitro vascular and whole animal approaches. We are defining the effects of telomerase inhibition or activation (global and mitochondrial) on ANG II-induced endothelial dysfunction (human and mouse). Cell culture models are used to investigate important regulators of cellular redox environment (NO/ROS balance).
Presented by
Aron Geurts, PhD
Aron Geurts, PhD
Associate Professor
Department of Physiology
Medical College of Wisconsin
About Dr. Geurts
Continuing research efforts in the Geurts lab are being driven by our interests in developing genetic approaches toward understanding human health and disease. For the past 12 years, we have been developing tools for genetic manipulation in a variety of cell and animal systems including stem cells, zebrafish, mice and laboratory rats. These systems are among the most widely preferred models for genetic and physiological investigation into human disease, however, genetic approaches, especially in non-mouse systems, have traditionally been limited by a lack of technologies.
After joining the Medical College in 2006, we implemented new approaches to accelerate transgenic and gene knockout studies for the PhysGen Program for Genomic Applications by adapting the Sleeping Beauty transposable element system for use in rats. Transposons are currently the most reproducible and efficient tool available for adding new genes to the rat genome and since then, we have worked with several other local investigators to create new transgenic rat models.
In 2009, we were fortunate to be the first to demonstrate that engineered proteins called Zinc Finger Nucleases (ZFNs) could be applied to rat embryos to generate the world’s first targeted gene knockout rats. This breakthrough revolutionized the local and broader research communities who use laboratory rats as a model system and other researchers are now applying these methods to other animal models such as mice, pigs, and rabbits. Site-specific modification of the rat genome using ZFNs is used to disrupt (knockout) or introduce specific gene alleles (knockin) to modify gene function. To date, we have created more than 100 knockout and knockin genetic models for several research areas related to our collaborative interests in complex diseases such as hypertension, renal disease, Type 1 Diabetes, and drug abuse.
More recently, the Geurts lab has been developing TAL Effector Nuclease (TALEN) technology for targeted genome engineering. TALENs are a relatively new technology which are analogous to ZFNs, but have some attractive attributes including reduced cost and design flexibility which will facilitate their use in the field. This new technique is complemented by our recent development of the first rat embryonic stem cells from a hypertensive rat model in collaboration with the laboratory of Dr. Howard Jacob. The availability of stem cells from this disease model rat now provides unique possibilities for creating more complicated genetic models. We are currently establishing whether these cells are capable of supporting our engineering approaches for producing genetically modified rats.
Recently, Dr. Geurts’ creative and innovative contributions to the field of genetics and technology were recognized by the granting of a New Innovator Award from the Office of the Director of the National Institutes of Health. This prominent award will propel efforts in the Geurts lab toward pushing the limits of these technologies to create better models of human disease. These techniques, animal models, and resources broadly benefit the local and broader research communities and advance our collective understanding of complex human genetic diseases.
MCW’s Global Health week is November 27-December 1, 2017. It was created to:
1) Increase the visibility of faculty’s global health activities in community engagement, clinical care, education, and research.
2) Raise awareness of local and international partnerships that are addressing global health issues from neighborhoods to nations.
The Department of Obstetrics & Gynecology has a long history of global health involvement. Current faculty members have traveled to provide global health care for women in multiple countries. These experiences have enriched their careers and provided unique experiences. Residents are encouraged to partake in experiences abroad during their training as well.
Panel Objectives:
– Review the variety of experiences that OBGYN practitioners have had abroad
– Listen to personal stories of meaningful experiences during global health work in women’s health
– Learn about the professional impact one gets from traveling abroad and providing health care
– Hear what an ideal vision of global health education in residency looks like from a variety of practitioners
Jennifer McIntosh, DO
Maternal Fetal Medicine specialist who has a special interest in global health. She’s spent time as a trainee (both as a medical student and resident) in Guatemala, Malawi and Kenya. She considers herself an advocate for global health during medical education and hopes to advocate for residents and students to gain obstetric experiences internationally.
Seema Menon, MD
General OB/GYN with subspecialty training in Adolescent Gynecology who has a very special interest in global health. She created our department’s “International Scholars in Obstetrics and Gynecology Program” with our first connection being with Shijiazhuang City Maternity and Child Health Hospital.
Allison Linton, MD, MPH
General OB/GYN with subspecialty training in Family Planning. She has a special interest in global health teaching and clinical care, focusing on improving women’s health outcomes through improving access to safe and comprehensive family planning services. She has taught and provided clinical services in Africa, Asia, and Central America.
Kathryn Sarnoski, MD
MCW OB/GYN resident graduate of 2017 and a current generalist in Obstetrics and Gynecology through Columbia St. Mary’s Hospital. She has an interest in global health primarily in Central and South America and has created the Global Health Resident Travel Fund in the Department of Obstetrics & Gynecology to promote resident education in global health. She volunteers as a provider and educator at CerviCusco in Cusco, Peru to address their high rates of cervical cancer morbidity and mortality. She also serves on the Board of Directors for the International Cervical Cancer Foundation
Presented by
Pamela Kreeger, PhD
Pamela Kreeger, PhD
Associate Professor
Vilas Associate
Dept. of Biomedical Engineering
University of Wisconsin-Madison
Dept. of Cell and Regenerative Biology,
Dept. of Obstetrics and Gynecology
University of Wisconsin School of Medicine and Public Health
Dr. Kreeger’s Research
Dr. Kreeger is working to develop a novel model of the retinal microenvironment to determine the impact of microenvironmental properties and cell-cell interactions on angiogenesis in age-related macular degeneration (AMD). Her background is in developing in vitro models of tissues (including her graduate work developing a system for the ovarian follicle and work from her independent lab to develop systems to study cell-cell interactions in ovarian cancer) and utilizing systems biology modeling to study cell behavior. Her current AMD-related project is in collaboration with Kristyn Masters (BME) and will involve interactions with McPherson ERI colleagues Jeremy Rogers and David Gamm.
About the Kreeger lab
The Kreeger lab utilizes systems biology and tissue engineering to analyze cellular behavior in a variety of biological contexts. We utilize an iterative approach, where we develop model culture systems that allow us to study a disease in a controlled environment, use high-throughput experimental methods to gather information about the cellular signaling network and cellular responses, and employ computational models to interpret the data. Ultimately, our models will be utilized to identify new drug targets, match patients to the most effective drugs, and identify methods to direct cellular behavior.
Presented by
Sridhar Rao, MD,PhD
Sridhar Rao, MD, PhD
Associate Investigator
Blood Research Institute
Blood Center of Wisconsin
Dr. Rao’s Research
In Dr. Rao’s laboratory, researchers are discovering how leukemia develops. Stem cells are defined by two unique properties: self-renewal, or the ability to undergo symmetric cell division to maintain a stable pool, and “potency”, or the ability to differentiate down multiple lineages. In the case of embryonic stem (ES) cells, their unique ability to differentiate into all three germ layers that form the embryo is termed pluripotency. Adult stem cells, such as the hematopoietic stem cell (HSC), are more restricted in their differentiation potential, but can fully recreate a tissue in vivo. Recently, the stem cell model has been extended into cancer, with cancer stem cells identified in certain malignancies such as acute myeloid leukemia (AML). While many of the factors required for stem cells are well described, none have been shown to play a critical role in all types of stem cells. Factors critical for all three stem cell types would likely operate by controlling a specific “stemness program” used by all stem cells for self-renewal and/or multipotency. Identification of such a program could provide new avenues to identify stem cells in vivo, enhance the reprogramming/generation of stem cells for use in regenerative medicine, and provide novel targets for the development of anti-cancer therapeutics.
Presented by
Alison Kriegel, PhD
Alison Kriegel, PhD
Associate Investigator
PhD Physiology
Medical College of Wisconsin
Dr. Kriegel’s Research
Our research is broadly centered on understanding how alterations in microRNAs and protein coding genes influence cardiovascular disease, renal disease, and cardiorenal syndromes. Cardiorenal syndromes are a grouping of human clinical conditions where primary disease in either the heart or the kidney contributes to the development of secondary disease in the other organ.
Our current focus is on cardiorenal syndrome type 4 (CRS4), also known as chronic renocardiac syndrome, a condition in which chronic kidney disease (CKD) contributes to the development of cardiovascular diseases including hypertrophy, diastolic dysfunction, reduction in cardiac function and increased risk of cardiovascular events.
CRS4 is clinical problem that has received a great deal of attention in recent years because of the large number of people impacted and the high associated healthcare costs. In 2010 the Centers for Disease Control estimated that more than 10% of adults in the United States population chronic kidney disease, and cardiovascular pathology is leading cause of death in these patients. Treatment of CRS4 remains challenging because so little is understood about the pathology of the disease. Adult patients with CKD often have age associated comorbidities, such as diabetes, hypertension, and atherosclerosis, making it difficult to identifying mediators of the pathology in this population.
Our goals are focused on identifying the essential components of cardiorenal syndromes and their therapeutic targets. We have started to investigate the molecular mediators of this conditions using a 5/6 nephrectomy (5/6 NX) model of CKD in Sprague Dawley rats. This model of CKD allows us to study CRS4 related pathologies in the absence of confounding comorbidities that would independently impact the heart, such as atherosclerosis, diabetes and hypertension.
Our current goals in CRS4 research interest include:
-Identifying pathways involved with CRS4 disease progression
-Understanding miRNA regulation of pathways involved with pathological LV remodeling and dysfunction in a rat model of CKD
-Circulating factors in CKD that contribute to the development of CRS4
We combine in vivo approaches for studying cardiac and renal function with advanced molecular techniques to comprehensively study the factors that influence left ventricular pathology. Frequently utilized techniques in our laboratory include: echocardiography, left ventricle pressure-volume relationship analysis, chronic and acute blood pressure recordings, cell culture models (siRNA, miRNA), in vitro and in vivo miRNA suppression, immunohistochemistry, in situ hybridization, western blot analysis, ELISA, miRNA and mRNA next generation sequencing and qRT-PCR.
Research for this project is supported an American Heart Association Scientist Development Grant (13SDG17100095).
Presented by
Sunila Pradeep, PhD
Assistant Professor
Department of Obstetrics & Gynecology
Medical College of Wisconsin
Dr. Pradeep’s Research
Peritoneal seeding is the most common pathway for the spread of ovarian cancer. Because 90% of ovarian cancers are surface epithelial carcinomas, the tumor cells are able to slough off the ovary and enter the peritoneal circulation, thereby seeding multiple sites in the abdominal cavity. Despite the widely-held view that epithelial ovarian cancer metastasizes via peritoneal seeding, the distribution of ovarian metastasis was peculiar in that the ovarian cancer cells gravitated toward the omentum, an apron tissue over the abdomen as the preferred site of metastasis. The omentum is composed of fatty tissue interspersed with immune cell aggregates or “milky spots”, consisting of macrophages, leukocytes, stem and progenitor cells, fibroblasts, and endothelial cells. It is known that disseminated tumor cells adhere to milky spots within hours, and milky spots are sources of cytokines and chemokines sites that facilitate local proliferation of tumor cells, and maturation of macrophages. Given the highly metastatic nature of ovarian cancer, we have an interest in understanding the mechanisms of how immune cells facilitate omental metastasis of ovarian cancer cells.
Our previous work at MD Anderson has demonstrated increased expression of neuregulin 1 (NRG1), the binding partner of ErbB3 (Erb-B2 Receptor Tyrosine Kinase 3), promotes homing of ovarian cancer cells to the omentum (Pradeep et al., Cancer Cell, 2014). In my lab at MCW, we will investigate how adipocytes reprogram the immune cells in omentum to enhance ovarian cancer cell progression and metastasis. We believe that these new mechanisms will offer new options for therapy targeting ovarian cancer metastasis.
Presented by
Nita Salzman, MD, PhD
Professor
Department of Microbiology and Immunology
Medical College of Wisconsin
Dr. Salzman’s Research
The intestinal microbiota is a complex and primarily bacterial ecosystem that lives in a symbiotic relationship with its host. When maintained in a homeostatic relationship with the host, the microbiota carries out numerous critical functions for the host, related to nutrition, metabolism, immune maturation and host protection, and in this context becomes part of the host barrier to infection. The host immune system interacts with the intestinal microbiota, ultimately establishing and maintaining a homeostatic relationship with this vast ecosystem. Disruptions in either the host barrier or the microbial ecosystem can lead to homeostatic collapse and the development of intestinal inflammation in both animal models and in human disease.
Our laboratory is engaged in both basic and translational studies to investigate the innate mucosal immunology of the GI tract, with a focus on host-microbiome interactions and innate barriers to bacterial infection. Antimicrobial peptides (AMPs) are essential components of the host barrier. These are peptides with broad-spectrum antibiotic activity against bacteria, fungi, and viruses, but have been shown to have diverse additional roles both related and unrelated to host defense. Epithelial cells and circulating immune cells endogenously produce these peptides, as do bacteria. One of our primary interests is to understand the multifaceted in vivo roles of intestinal AMPs. Our work has focused primarily on enteric alpha-defensins, produced in Paneth cells localized to the small intestinal crypts. Previous work in our lab demonstrated that Paneth cell defensins have an important role in protecting the mammalian host from enteric bacterial pathogen infection. Recent work from our laboratory has shown that Paneth cell defensins are essential regulators of the composition of the intestinal microbiota, and can modulate mucosal immune responsiveness through their regulation of the microbiota.
Recently, we have translated our findings to the study of Paneth cell antimicrobial peptides (AMPs) in pediatric Crohn’s disease (CD). CD, one of the subtypes of inflammatory bowel diseases manifests with chronic intestinal inflammation and is associated with abnormal bacterial growth at mucosal surfaces (dysbiosis). Several genetic mutations that have been associated with increased risk for the development of CD have also been associated with Paneth cell dysfunction. As part of the Crohn’s and Colitis Foundation of America (CCFA) Microbiome Consortium, we are investigating the relationship between Paneth cell dysfunction and dysbiosis in pediatric CD patients.
A second translational study focuses on the role of the microbiome in the development and progression of pediatric non-alcoholic fatty liver disease (NAFLD). NAFLD is associated with obesity and metabolic syndrome and its prevalence has increased in parallel to the prevalence of obesity and type-2 diabetes. The development of NAFLD, its different phenotypes, and the heterogeneity of disease progression are not completely understood. Recent evidence suggests that there is an association between intestinal microbial colonization (the intestinal microbiome) and obesity in humans and in animal models. In addition, there is evidence of abnormalities of bacterial colonization, and intestinal bacterial product induced inflammation associated with NAFLD and progression to NASH. This study investigates the composition of the intestinal microbiome in pediatric patients with obesity and obesity plus NAFLD, to determine the relationship between alterations in the intestinal microbiome, immune activation, and the development of NAFLD.
We have recently begun to investigate the basic mechanisms of bacterial colonization of the GI tract, using Enterococcus faecalis as a model organism. E. faecalis is a common commensal of the mammalian gut, but also an opportunistic pathogen, which is currently an important cause of infection in hospitalized patients. We have developed a novel system to colonize mice with marked laboratory strains of E. faecalis and are using this system to explore both bacterial-host and bacterial-microbiome interactions in the native mouse GI tract, to understand the important host and bacterial determinants essential for colonization and permissive/protective for systemic infection.
Presented by
Blake Hill, PhD
Professor
Department of Biochemistry
Medical College of Wisconsin
Dr. Hill’s Research
Defects in mitochondrial fission and fusion cause or contribute to human diseases including cancer, neuropathies, cardiomyopathies, and even death. Our goal is to understand molecular basis of these defects in order to identify new therapeutic routes for these diseases.
We determine how proteins interact with other biological macromolecules to control these basic membrane fission and fusion processes in healthy, diseased, and dying cells. We strive to understand these interactions on a physicochemical level, with an eye for gleaning universal principles of protein chemistry including interactions with membrane bilayers that are fundamental to a wide variety of cellular processes.
A key feature of some proteins that affect mitochondrial homeostasis is the structural transformation from soluble to membrane-bound conformations, a phenomenon referred to as amphitropism. Associating with, or dissociating from, a membrane (i.e. amphitropism) has significant functional consequences for numerous biological processes: it can affect enzymatic activity (CCT, PLC), can promote changes in organelle and cell morphology (MinD, dynamins), or can act as a regulatory switch in various signaling cascades (PKC, ESCRTs). However, neither what drives proteins to reversibly interact with membranes nor how this function controls biological outcomes are clearly understood. These interactions are likely governed by evolutionarily conserved mechanisms that are still being determined and is one focus of our efforts.
Towards these goals, we use a wide range of tools including genetic, cell biological, biochemical, and biophysical methods including NMR spectroscopy and x-ray crystallography for protein structure determination.
Presented by
Shahram Eisa-Beygi, PhD
Kelleigh Gustafson Research Fellow
Department of Radiology
Medical College of Wisconsin
Dr. Eisa-Beygi’s Research
I am interested in identifying the mechanisms of neuro-vascular development, with a focus on the etiology of paediatric cerebral-vascular disorders, including cerebral aneurysms and arterio-venous malformations.
This talk will review the association between obesity and gynecologic cancers, our understanding of why this association exists and what changes can be made to prevent cancer and improve outcomes.
Presentation by Dr. Erin Bishop, gynecologic oncologist.
Please join the Kern Institute, Department of Medicine and Department of Obstetrics and Gynecology for an interactive dialogue.
Have you ever witnessed events that challenged professionalism but didn’t speak up or follow up? Let’s have a discussion about being courageous and speaking up in a professional way to improve our culture of caring and character.
Speakers
Catherine (Cassie) Craun Ferguson, MD, Associate Professor of Pediatrics
Kristina Kaljo, PhD, Assistant Professor of Obstetrics and Gynecology
Michael Lund, MD, Associate Professor of Obstetrics and Gynecology
Martin Muntz, MD, Associate Professor of Medicine
By attending this session, participants will:
- Identify skills to utilize when responding to problems and/or concerns
- Discuss methods to support the well-being of oneself and others
- Analyze events which could have been avoided/deescalated if someone intervened
Kern Institute Cafe Discussion
Please join us for a cafe conversation led by Andrew Petroll, MD and Jessica Francis, MD on “Understanding Gender Identity: Taking a Deeper Dive”. All students, faculty, and staff are welcome to join us.
If you have a family history of cancer, this may have important health implications for you and your relatives. Find out about genetic testing for cancer along with the options for cancer prevention and early detection.
Presentation by: Jennifer Geurts, MS, CGC, Certified Genetic Counselor.
Presented by
Marcelo Bonini, PhD
Associate Professor
Endocrinology
Medical College of Wisconsin
Miscarriage is unfortunately a fairly common occurrence among reproductive age women, but it can be an emotionally difficult event. In this lecture, we hope to educate about the etiologies of miscarriage, explain the evaluation and treatment options for recurrent miscarriages and discuss the importance of stress reduction and self-care for those struggling with miscarriage.
Speakers
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| Abbey Kruper, PsyD Assistant Professor Women's Health Psychologist | Kate Schoyer, MD Associate Professor Reproductive Endocrinologist |
Presented by
Amanda Johnson, MD
Maternal–Fetal Medicine Fellow
Department of Obstetrics & Gynecology
Medical College of Wisconsin
About
Dr. Mandy Johnson joined the department as a fellow in maternal fetal medicine in July 2016. She attended medical school at University of North Dakota School of Medicine and Health Sciences from 2006-2010. She completed residency at Tulane University in New Orleans, LA in 2014.
Dr. Johnson’s research interests include preterm labor and infectious disease. Her residency research project compared genital and plasma HIV viral load levels in pregnant patients.
She is an active member of American Congress of Obstetricians and Gynecologists. She also received the Outstanding Residency Performance award at the end of her residency.
Presented by
Marja Nevalainen, MD, PhD
Marja Nevalainen, MD, PhD
Professor, Eminent Scholar, Department of Pathology and Pharmacology & Toxicology
Assistant Dean of Research
Associate Director of Education & Training, Medical College Cancer Center
Director of the Prostate Cancer Center of Excellence
Medical College of Wisconsin
About
Dr. Nevalainen is an internationally recognized leader in the field of cytokine and steroid hormone signaling in prostate cancer. The focus of her laboratory is on translational prostate cancer research to develop and improve diagnostics and therapy for prostate cancer. Dr. Nevalainen holds the title of Eminent Scholar at MCW. She is also Director of Prostate Cancer Center of Excellence at MCW Cancer Center, which is a multi-disciplinary hub for prostate cancer research with an international collaborative network. Dr. Nevalainen serves as Assistant Dean for Research at MCW, and Associate Director of Education for the MCW Cancer Center. Her primary appointment is in the Department of Pathology, and a secondary appointment in the Department of Pharmacology and Toxicology. Dr. Nevalainen has extensive experience in collaborative research, mentoring and leadership from her previous roles at Sidney Kimmel Cancer Center at Thomas Jefferson University as Associate Director of Education and Vice Chair of Education in the Department of Cancer Biology.
Dr. Nevalainen’s research accomplishments include development of an androgen-dependent human PC cell line which mimics the course of human disease when grown as xenograft tumors in nude mice. Specifically, the tumors response to androgen deprivation by regression but regrow eventually back as castrate-resistant tumors.
Dr. Nevalainen is further recognized in her field for early development of a long-term 3D tumor explant culture system for normal and malignant prostate tissue for efficacy testing of experimental biologics and small-molecules ex vivo in clinical PCs from patients and as an experimental model system for identification of growth factor and drug modulated signaling proteins in prostate tissue.
Current work focuses on Jak-Stat signaling in anti-androgen resistance of prostate cancer, Stat5 regulation of DNA repair and optimization of the lead compound Stat5 inhibitor.
The Council for Women’s Advocacy and the Center for AWSM are hosting Dr. Kate Dielentheis and Dr. Mona Farez for a presentation on work-life balance: “Say Yes By Saying No”.
Why is my period back? This may be a sign of uterine cancer. Learn why a period after menopause warrants medical evaluation
Presentation by
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| Lisa Caravella, APNP Gynecologic Oncologist Nurse Practitioner | Jamie Neary, APNP Gynecologic Oncologist Nurse Practitioner |
Presented by
Nicole Lohr, MD, PhD, FACC
Nicole Lohr, MD, PhD, FACC
Assistant Professor, Department of Medicine, Division of Cardiovascular Disease and Internal Medicine
Medical College of Wisconsin
Please join us for CTSI’s next Science Cafe – an educational discussion led by Dr. Denise Uyar about the significant role that viruses, such as the human papillomavirus, play in the development and spread of specific cancers. We will also discuss screenings and prevention for specific cancers.
Presentation by: Denise Uyar, MD, Gynecologic Oncologist Physician.
Miscarriage is unfortunately a fairly common occurrence among reproductive age women, but it can be an emotionally difficult event. In this lecture, we hope to educate about the etiologies of miscarriage, explain the evaluation and treatment options for recurrent miscarriages and discuss the importance of stress reduction and self-care for those struggling with miscarriage.
Speakers
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| Abbey Kruper, PsyD Assistant Professor Women's Health Psychologist | Kate Schoyer, MD Associate Professor Reproductive Endocrinologist |
Presented by
Magdalena Chrzanowska-Wodnicka, PhD, FAHA
Magdalena Chrzanowska-Wodnicka, PhD, FAHA
Associate Professor, Department of Pharmacology and Toxicology
Medical College of Wisconsin
Investigator
The Blood Research Institute
Learn about prevention, detection and treatment of HPV.
Presentation by: William Bradley, MD, Gynecologic Oncologist Physician.
Presented by
Brian Smith, PhD
Brian Smith, PhD
Assistant Professor, Department of Biochemistry
Medical College of Wisconsin
Come and listen to our panelists tell their stories about the barriers trans and gender non-conforming patients may face while seeking health care, and ways to show compassion and provide quality care. This program is designed for our clinical faculty and students but is open to all.
Panelists
- Jessica Francis, MD, Associate Residency Program Director, Assistant Professor, Department of OB/GYN
- Jenna Sarvaideo, DO, Assistant Professor, Department of Medicine – Endocrinology
- Nathan Lamberton, PharmD, Assistant Professor, School of Pharmacy
- Kaci Sullivan, transmasculine parent and birth giver
- T.S. Banks, poet, playwright, and disability justice advocate
Why is my period back? This may be a sign of uterine cancer. Learn why a period after menopause warrants medical evaluation
Presentation by
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| Lisa Caravella, APNP Gynecologic Oncologist Nurse Practitioner | Jamie Neary, APNP Gynecologic Oncologist Nurse Practitioner |
Presented by
Jennifer McIntosh, DO, MS
Assistant Professor, Department of Obstetrics & Gynecology, Division of Maternal-Fetal Medicine
Medical College of Wisconsin
Dr. McIntosh’s Research
Maternal and neonatal morbidity and mortality caused by preeclampsia is a significant global health burden with approximately 10 million pregnancies impacted resulting in nearly half a million fetal or neonatal lives lost each year. A novel relationship may exist between mitochondrial damage and endothelial dysfunction and subsequent development of preeclampsia.
Our overall goal is to investigate the mechanism whereby placental hypoxia is responsible for release of ROS and inflammation secondary to mitochondrial DNA (mtDNA) and if there is altered FMD as a result of heightened mtDNA in vessels from placentas in those with preeclampsia.
The next CTSI Science Café will be held on Tuesday, May 28, from 5:30 – 6:30 p.m. at St. Ann Center for Intergenerational Care (Bucyrus Campus), located at 2450 W. North Avenue in Milwaukee.
The May topic will be Examining the Link Between Human Papillomavirus (HPV) and Cervical Cancer. The discussion will be led by Denise Uyar, MD, associate professor of obstetrics and gynecology in the Froedtert & the Medical College of Wisconsin Cancer Center. The presentation will be followed by a community conversation on topic.
CTSI Science Café is free and open to the public by registering here. Light refreshments will be served.
For more information, please contact Angie Holtz, aholtz@mcw.edu or 414-955-2540.
Presented by
Curt D. Sigmund, PhD
Curt D. Sigmund, PhD
James J. Smith & Catherine Welsch Smith Professor and Chair, Department of Physiology
Associate Director, Cardiovascular Center
Medical College of Wisconsin
Dr. Sigmund’s Research
Dr. Sigmund’s major areas of research focus on central nervous system and vascular mechanisms of blood pressure regulation by the renin-angiotensin system, the transcription factor PPAR-gamma, and its downstream effectors Cullin-3/RhoBTB1, investigating these using a combination of molecular biological, genetic and physiological approaches including the generation of unique transgenic and knockout models. Dr. Sigmund’s laboratory is located within the Cardiovascular Center in the Health Research Center and Medical Education buildings.
Finding accurate information about fibroids can be difficult especially in regards to diagnosis and treatment. Dr. Beran and Dr. Fairchild have teamed together to offer a collaborative clinic for consulting on challenging cases of uterine fibroids. This class will provide a better understanding of uterine fibroids highlighted by a thorough review of treatment options.
Presentation by: Benjamin Beran, MD, and Alexandra Fairchild, MD.
What’s in an Annual? The Who, What, When and Why of Preventative Gynecology Care. Learn about the new advances, changes and recommended screenings in women’s health.
Presentation by: Amy Domeyer-Klenske, MD.
Presented by
Mark Santillan, MD, PhD, FACOG, FAHA
Mark Santillan, MD, PhD, FACOG, FAHA
Assistant Professor of Obstetrics and Gynecology – Maternal Fetal Medicine
Faculty, Molecular and Cellular Biology
Clinical Research Director, Maternal Fetal Tissue Bank
Co-Director, OB/GYN Residency Research
Carver College of Medicine
Dr. Santillan’s Research
The Santillan lab is particularly interested in the relationship between maternal health during pregnancy and the short and long-term health effects to the mother and child. Specifically, our current work focuses on the early mechanisms involved in the development of preeclampsia, including immunological and vascular function changes during pregnancy. A central focus in the lab is investigating the predictive, preventative, therapeutic and curative potential of the arginine vasopressin pathway in preeclampsia. Leveraging the group’s novel discovery of a very early biomarker for preeclampsia and a novel mouse model for preeclampsia, our lab works to investigate the mechanistic underpinnings of the predictive and therapeutic potential of vasopressin in the management of preeclampsia in a translational manner. As a practicing academic high-risk obstetrician, Dr. Santillan is very qualified in caring for women with high risk pregnancies, in understanding their clinical management, and in conducting clinical/translational research in perinatal biology. He has been successful in conducting studies in both murine and human pregnancies. As the clinical research director and co-founder of the Maternal Fetal Tissue Bank, Dr. Santillan has significant experience in clinical data acquisition, management, and analysis as well as molecular biology techniques needed for translational studies. Furthermore, as the Principal Investigator of the Population project of the University of Iowa American Heart Association Strategically Focused Research Network in Hypertension, Dr. Santillan has developed the PREDICTV network of prenatal providers around the state of Iowa to collect samples and clinical information from a diverse cohort of pregnant women.
Endometriosis typically presents with painful periods, painful intercourse, chronic pelvic pain or infertility. Despite being a common finding, a lot of misinformation exists on endometriosis. Gain a better understanding of endometriosis through accurate medical information.
Presentation by: Benjamin Beran, MD, and Camila Bomtempo, MD.
When significant breastfeeding challenges are expected or met, creating a plan ahead of time can reduce stress and improve the breastfeeding experience
Presentation by: Sarah Mess, CNM.
Presented by
Manish Patankar, PhD
Professor, Obstetrics & Gynecology, Division of Reproductive Sciences
Associate Director, Endocrine and Reproductive Physiology (ERP) Program
University of Wisconsin-Madison, School of Medicine and Public Health
About
Dr. Manish Patankar is a Professor in the Division of Reproductive Sciences. Dr. Patankar grew up in Thane, India, a city that borders Mumbai (Bombay). His wife is a physical therapist at the American Family Children’s Hospital and they have a 7 year old daughter who is in first grade at Glenn Stephens Elementary.
Dr. Patankar graduated from the University of Bombay, India with a B.S. in Chemistry in 1987. Subsequently, he received his Masters of Science in Organic Chemistry from the University of Bombay in 1990, and his Masters of Chemistry from Old Dominion University in Norfolk, Virginia in 1993. Dr. Patankar then completed his PhD in Biomedical Sciences at Eastern Virginia Medical School/Old Dominion University in 1998.
Dr. Patankar was an instructor and Research Professor at Eastern Virginia Medical School until 2004 when he joined the department as Professor and also became a member of the UW-Madison Carbone Cancer Center. His current research includes developing diagnostic tests for ovarian cancer and preeclampsia and strategies for treating ovarian cancer.
Collaborations at UW-Madison include: Drs. Joseph Connor, David Abbott, Paul Sondel, David Beebe, Ralph Albrecht, Mark Cook, Sean Fain, Ian Rowland, Hirak Basu and and Lingjun Li. Non UW-Madison collaborations include: Drs. Mitchell Ho and Ira Pastan (National Cancer Institute), Dr. Jennifer Gubbels (Augustana College, SD), Rebecca Whelan (Oberlin College, OH), Biotech Industry: Neoclone Biotechnology (Madison), and Gentel Biosciences (Fitchburg).
Dr. Patankar teaches Endocrine Physiology, Biology 151, and lectures on immunology in several different courses on campus.
What does he do in this spare time? He loves music and watching SpongeBob with his daughter.
One of the most interesting places that Dr. Patankar has visited is Bergen, Norway.
Research Focus
The primary focus of my research is to devise specific methods for early diagnosis of epithelial ovarian cancer (EOC) and to understand the effect of factors produced by ovarian tumors on the functional capacity of tumor infiltrating lymphocytes. This research involves extensive utilization of glycoproteomic analysis in conjunction with cellular immunology, molecular biology and glycobiology.
Learn basic information about how anxiety can present in women and develop strategies to manage distress in order to have a fuller life.
Presentation by: Abbey Kruper, PsyD, psychologist
Register Online
Register online through the link to Froedtert’s classes and events below.
Presented by
Stephanie Olivier-Van Stichelen, PhD
Assistant Professor, Biochemistry
Medical College of Wisconsin
About
Dr. Olivier-Van Stichelen received her PhD degree in Biochemistry from the University of Lille, France in 2012. Her work was focused on the understanding of the nutrient-sensing O-GlcNAcylation in colorectal cancer development with a special interest in diet-dependent modification of the oncogene beta-catenin.
After completion of her degree, she was appointed as a post-doctoral Fellow in the Laboratory of Cellular and Molecular Biology at the National Institute of Health, Bethesda, MD, USA. In this lab, Dr. Olivier-Van Stichelen worked on different aspects of O-GlcNAcylation during development including X-inactivation of the O-GlcNAc Transferase gene. She also developed a brain O-GlcNAcase knockout model and studied the impact of sugar consumption during pregnancy on O-GlcNAc-dependent development of metabolic homeostasis. More recently, she developed interests in understanding the importance of artificial sweeteners for offspring’s metabolism and microbiome.
Dr. Olivier-Van Stichelen established her lab at the Medical College of Wisconsin at the crossroad of sweeteners, pregnancy, development and metabolism.
Research Focus
Due to the global trend of growing sweetener consumption, determining the interplay between diet and pre- and post-natal development is emerging as a critical area for research. Currently, the average American eats around 22 teaspoons of added sugar every day (30 sugar cubes/day hidden in foods). This modern glucose-rich diet correlates with an increase in the prevalence of obesity, diabetes and others metabolic syndromes. Moreover, the effort to reduce sugar consumption has led people to consume more non-caloric sweeteners (Aspartame, Sucralose, Acesulfame-K…). While they appear healthier for glucose homeostasis than a high carbohydrate diet, recent studies have shown that artificial sweeteners impact glucose metabolism as well as gut microbiota, rising questions about their excessive use.
Therefore, understanding what happens when caloric and non-caloric sweeteners are metabolized is of utmost importance for public health and the focus of my research group.
Nutrient-dependent O-GlcNAc cycling in development and disease
O-GlcNAcylation is one of the key components of diet-responsive signaling. This unique glucose rheostat is a ubiquitous and dynamic glycosylation of intracellular proteins with approximately 1000 modified proteins described to date. Two key enzymes drive O-GlcNAc cycling: The O-GlcNAc transferase (OGT) adds the modification and the O-GlcNAcase (OGA) removes it. Although many studies have focused on the decrease or complete absence of O-GlcNAc cycling by modulating the expression or activity of OGT, only a few studies have targeted hyper-O-GlcNAcylation by disturbing OGA. Because this post-translational modification is directly dependent on glucose input, depleting OGA creates an artificial and constant hyperglycemia-induced O-GlcNAcylation state. Using Oga and Ogt knockout (KO) cellular and mouse models, we can decipher the impact of high carbohydrate diet on embryonic development.
Non-Nutritive Sweeteners in pregnancy and lactation
Part of my lab is interested in understanding the impact of Non-Nutritive Sweetener (NNS) consumption through pregnancy and lactation. Although, NNS have been found in mother’s milk and in placental blood circulation, no study has focused on the fundamental effect of those non-caloric sweeteners on the developing organism.
Among the impacts described in adults are changes in intestinal hormonal secretion, glucose metabolism and most fascinating, re- duction of the gut microbiota. Nevertheless, the fundamental mechanisms of those changes are far from understood. Glycoproteins found on the surface of the intestinal epithelium define the glycocalyx and are an essential mammalian mechanism of communication with the gut microbiome. Their reciprocal relationship with the gut microbiome regulates not only nutrient breakdown, and food absorption, but also infection. We are convinced that by altering both microbiome and the detoxification process, NNS exposure in early life will impact metabolic homeostasis later in life.
Presented by
Xiaowen Bai, MD, PhD
Xiaowen Bai, MD, PhD
Associate Professor, Cell Biology, Neurobiology & Anatomy
Medical College of Wisconsin
About
Dr. Bai’s research interests are centered on the application of stem cells on disease modeling and tissue regeneration. The current major focus of the laboratory is to utilize gain- and loss-of-function approaches to examine the novel molecular mechanisms underlying the roles of non-coding RNAs, mitochondria, and genetic factors in neurodegeneration and cardiotoxicity in mice, and translate the findings to humans using stem cell-derived brain cells, heart cells, three-dimensional mini brains, and heart organoids.
Research Area 1:
Non-coding RNAs, mitochondria, and cell stress-related genes in neurodegeneration:
Neurological disorders have emerged as a predominant healthcare concern in recent years due to their severe consequences on quality of life and prevalence throughout the world. Understanding the underlying mechanisms of these diseases and the interactions between different brain cell types is essential for the development of new therapeutics. Many drugs (e.g., anesthetics), environmental factors (e.g., alcohol), diseases, and genetic risks are related to neurodegeneration. We examine the novel molecular mechanisms underlying the roles of microRNAs, long non-coding RNAs, mitochondria, immediate early and other cell stress-related genes in neurodegeneration using both mouse, and human stem cell-derived brain cell and three-dimensional mini brain models
Research Area 2:
Stem cell-mediated myocardial regeneration
Myocardial infarction is one of the major causes of death throughout the world. Currently, there is not a highly effective approach for treatment. Stem cells hold promise in repairing injured cardiac tissue. Our lab is involved in studying the effect of the transplantation of adipose tissue-derived stem cells and induced pluripotent stem cell-derived cardiomyocytes on myocardial regeneration following ischemia injury. A molecular imaging method has been developed to investigate the molecular mechanisms controlling homing, engraftment, and survival of injected cells in vivo.
Research Area 3:
The mechanisms of impaired cardioprotection under diabetic conditions
Hyperglycemia has been shown to be particularly detrimental to the cardioprotective effects, with the underlying mechanisms remaining largely unknown. We have developed and validated a clinically relevant model of functional human cardiomyocytes derived from both normal induced pluripotent stem cells (iPSCs) and diabetes mellitus iPSCs. This in vitro model of human disease will enable developmental and comparative studies of normal and diabetic cardiomyocytes to address genetic and environmental mechanisms responsible for attenuation of cardioprotection signaling in diabetics.
Urinary issues including urgency and leakage are not something you should have to live with or schedule your life around. Learn about types of leakage and the options that exist for treatment.
Presentation by: Emily Davidson, MD, Urogynecologist
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We will take a look at the latest research on reproductive nutrition to improve your chances of conceiving.
Presentation by: Carol A. Eling, Advanced Practice Nurse Practitioner
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Register online through the link to Froedtert’s classes and events below.
Presented by
Paul Campagnola, PhD
Professor, Biomedical Engineering
University of Wisconsin-Madison
About
Campagnola’s research is directed toward developing high resolution imaging modalities. The technologies his group has developed can readily be applied to problems in eye and vision research. For example, the technique of Second Harmonic Generation (SHG) to image collagen fibrillar structure has been used by other labs to image the corneal structure. Expanding into eye research is a natural direction for the Campagnola Laboratory.
Alterations to the extracellular matrix (ECM) composition and structure are thought to be critical for tumor initiation and progression for several epithelial carcinomas, including those of the ovary and breast. Our lab develops Second Harmonic Generation (SHG) microscopy tools to quantitative assess these alterations in the stroma where we correlate the optical signatures with structural changes in the fibrillar assembly between normal and diseased tissues. This physical approach provides objective measurements that may be used to understand disease progression. To further investigate how remodeling enables invasion and metastasis in vivo we use multiphoton excited (MPE) photochemistry to fabricate biomimetic in vitro models of the ovarian ECM. The nano/microstructured models simulate the crosslinked fibrillar structure of the native ECM.
Tissue engineering has vast potential to improve human health by repair and maintenance of existing tissue or generation of replacement of tissues and organs. A major limitation has been an incomplete understanding of the underlying cell-ECM interactions that govern cell adhesion which will ultimately affect downstream functions. Our approach to this problem utilizes MPE photochemistry to create 3D biomimetic scaffolds directly from crosslinked proteins. Beginning with bio-inspired designs we will seek to achieve improved function.
CARDIOVASCULAR CENTER MEMBER PRESENTATION
Jenn McIntosh, DO, MS – Perinatologist
Resident and Fellow Research and Alumni Day is an annual event where our residents and graduating fellow present their clinical, translational science, and educational research results within their residency and fellowship in the Department of Obstetrics and Gynecology.
Due to COVID-19, this event will be virtual. Register with the link below to receive the Webex information.
Agenda
| Time | Activity |
|---|---|
| 7:45am | WELCOME |
| 8:00am | Rachel Harrison, MD, MFM Fellow Fibroblast Growth Factor 21 Placental Levels in Infants with Macrosomia Mentors: Meredith Cruz, MD & John Corbett, PhD |
| 8:15am | Precious Gaddis, MD, R4 The Prevalence and Impact of the Treatment of Vitamin D Deficiency in Patients undergoing In Vitro Fertilization Mentor: Jayme Bosler, MD |
| 8:30am | Brian Tillis, MD, R4 Effect of a Best-Practice Alert on the Rate of Smoking Cessation among Pregnant Women Mentor: Anna Palatnik, MD |
| 8:45am | Bradley Corbin, MD, R3 Enhanced Recovery After Surgery (ERAS) Protocols: Preoperative Education: Patient Satisfaction Outcomes Mentor: Denise Uyar, MD |
| 9:00am | Spencer Gantz, MD, R3 Obstetric Outcomes in Pregnancies Complicated by Maternal Congenital Heart Disease Mentor: Erika Peterson, MD |
| BREAK | |
| 9:15am | Colin Johnson, MD, R3 Assessment of the Immunologic and Clinical Significance of the Variable Microsatellite Instability Phenotype Observed in MMR-Deficient Endometrial Cancer Mentor: William Bradley, MD |
| 9:30am | Lauren Kurtz, MD, R3 Comparison of Hypertensive Disorder of Pregnancy Prevalence in Patients with Anxiety and Depression with or Without the Use of Psychotropic Medication Mentor: Anna Palatnik, MD |
| 9:45am | Theresa Piquette, MD, R3 Obesity and Embryodynamics: Effect of BMI on Embryo Division Timing in Patients Undergoing IVF Mentor: Kate Schoyer, MD |
| 10:00am | Ashley Verhasselt, MD R3 Attitudes, Barriers and Needs of Healthcare Providers Providing Breastfeeding Support at Froedtert Hospital Birth Center Mentors: Kristina Kaljo, PhD & Kate Dielentheis, MD |
| 10:15am | Kate Wlodarczyk, MD Neonatal Outcomes and Frequency of Ultrasound in Women with Prior Bariatric Surgery Mentors: Meredith Cruz, MD & Rachel Harrison, MD |
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2020 Resident Graduates
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Kathryn Carnahan, MD
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Talia Coney, MD
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Precious Gaddis, MD
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Justin Harold, MD
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Sarah Hirsch, DO
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Isabel Nellen, DO
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Brian Tillis, MD
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Cindy Vu, MD
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2020 Maternal-Fetal Medicine Fellowship
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Rachel Harrison, MD
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Please join the Department of Obstetrics and Gynecology for the Student-Centered Pipeline to Advance Research in Cancer Careers (SPARCC) Cancer Research Summit and graduation on August 7, 2020, from 10:30 a.m.-12 p.m. This will be a virtual event, where the scholars will have the opportunity to share their research and open it up for questions and brief discussions for each presentation. We will conclude the event by “presenting” graduation certificates and acknowledging each scholar’s participation this summer.
Program:
10:30-11:30 a.m.: Research Presentations – Topics are centered on “wicked problems” found in cancer-specific research.
11:30 a.m.-12 p.m.: Graduation Ceremony – SPARCC Co-Directors Janet Rader, MD, and Kristina Kaljo, PhD, will present each of the scholars with a certificate of completion.
If you would like to attend, please email us at sparcc@mcw.edu.
SPARCC is an intensive 8-week summer program that immerses undergraduate students from backgrounds underrepresented in biomedical research in the complexities of clinical cancer research. To learn more, please visit obgyn.mcw.edu/sparcc.
Please join us virtually. This talk will detail what constitutes a significant family history along with discussion of genetic testing. The talk will also touch on management of hereditary cancer syndromes, such as Lynch syndrome and BRCA.
Presentation by: Elizabeth Hopp, MD, Gynecologic Oncologist
Register Online
Register online through the link to Froedtert’s classes and events below.
Please join us virtually to learn basic information about how anxiety can present in women and develop strategies to manage distress in order to have a fuller life.
Presentation by: Abbey Kruper, PsyD, psychologist
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Register online through the link to Froedtert’s classes and events below.
Please join us virtually! This talk is geared towards giving both individuals and couples the knowledge to make informed decisions about how to best go about building their families or preserving their fertility. During this time we will dispel common myths surrounding fertility and answer any questions you may have. We will also cover red flags that could mean a potential risk for infertility down the road.
Presentation by: Bo Rydze, MD, Reproductive Endocrinologist
Register Online
Register online through the link to Froedtert’s classes and events below.
Please join us virtually! We will discuss what preeclampsia is and the signs and symptoms to watch for in pregnancy, as well as how it’s managed.
We will also explain the impact of preeclampsia on a woman’s future heart health.
Presentation by: Jennifer Jury McIntosh, DO, Perinatologist
Register Online
Register online through the link to Froedtert’s classes and events below.
Please join us virtually! Women with existing autoimmune diseases may be at higher risk of infertility and some autoimmune conditions can increase a woman’s risk of miscarriage.
Together we will discuss these conditions and what to do to increase your chances of a successful pregnancy.
We will also explain the impact of preeclampsia on a woman’s future heart health.
Presentation by: Jayme Bosler, MD, Reproductive Endocrinology and Infertility physician
Register Online
Register online through the link to Froedtert’s classes and events below.
Urinary issues including urgency and leakage are not something you should have to live with or schedule your life around. Learn about types of leakage and the options that exist for treatment.
Presentation by: Emily Davidson, MD, Urogynecologist
The Milwaukee Film Festival and Froedtert & the Medical College of Wisconsin present Black Birth: A Maternal Health Conversation and Resource Fair.
The short film Black Birth serves as the backdrop to a community dialogue about the joys, fears, complexities, and disparities of Black motherhood in America and locally in Milwaukee. Following the film screening will be a panel discussion including an OB-GYN physician and resident, community doula, African American breastfeeding expert, and other maternal-fetal care specialists, as well as a resource fair featuring leading health and wellness community partners.
This in-person event is FREE and open to the public. Space is limited to the first 150 people. Masks are REQUIRED and will be provided if needed. There is no virtual option. No Tickets required.
| Time | Topic |
|---|---|
| 11:00 AM | Welcome and Introduction |
| 11:15 AM | Short Film |
| 11:45 AM | Discussion |
| 12:15 - 1:00 PM | Panel Questions and Discussion |
Panelists
- Moderator: Amy Domeyer-Klenske, MD – Obstetrician and Gynecologist
- OBGYN Providers: Seema Menon, MD – Obstetrician and Gynecologist and Ciera Oshodi, MD – OBGYN Resident
- Breastfeeding Expert: Dalvery Blackwell, BA, IBCLC with the African American Breastfeeding Network I
- Doula
- Patient
Join us September 25th for the Ray of Hope’s 3rd Annual Race! Help us run or walk to raise funds for ovarian cancer. All proceeds go directly to our researchers working hard to identify novel targets and treatment strategies to cure ovarian cancer.
Ray of Hope is a non-profit organization established in 2018 in the Greater Milwaukee Area in response to the need for more advocacy for ovarian cancer awareness and research. Ray of hope provides philanthropic support to ovarian cancer researchers like us to generate preliminary data to apply for high-risk and high-reward federal grants. Ray of hope believes in the bravery of all women who have fought or are fighting against ovarian cancer. Ray of hope is working for women around the globe to be brave and resilient in the fight against ovarian cancer – – and their bravery should not go unnoticed.
Sunila Pradeep, PhD’s laboratory is partnering in the mission of Ray of Hope by identifying novel targets and treatment strategies to cure ovarian cancer.
Please join us as we discuss how groups can successfully navigate collective trauma with the COVID-19 pandemic as a model. It is how we cultivate resilience as a group, foster communication and individually and collectively recover and grow that determines whether an initial trauma will cause additional fall out. We propose to review some best practices for how to collectively navigate “pandexit” or recovery from any traumatic or stressful situation that affects a large group of people. In this session, we will discuss individual and group tools for resilience, go over acute and chronic reactions to trauma and discuss how leadership can steer groups of people into recovery.
Speakers:
- Kate Dielentheis, MD, assistant professor of obstetrics and gynecology
- Kristy Graettinger, MD, associate professor of obstetrics and gynecology
- Abbey Kruper, PsyD, associate professor of obstetrics and gynecology, psychiatry and behavioral medicine