Calendar of Events

Sep
27
Wed
2023
2023 Annual Sterner Lecture for Fetal Medicine @ MCW Alumni Center
Sep 27 @ 8:30 am – 9:30 am

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Featured Speaker: George B. Mychaliska, MD – “Leveraging Intrauterine Physiology – Fetal Surgery and the Artificial Placenta”

George B. Mychaliska, MD

Professor, Pediatric Surgery, Surgery
University of Michigan Health

George B. Mychaliska, M.D. is the Robert Bartlett, MD Collegiate Professor of Pediatric Surgery and a Professor of Obstetrics and Gynecology at the University of Michigan. He earned his Medical Degree and Master’s of Science from the Joint Medical Program at the University of California at San Francisco and Berkeley. He completed his General Surgery residency and Fetal Surgery fellowship at UCSF. Dr. Mychaliska completed his Pediatric Surgery fellowship at the Children’s Hospital of Michigan. He is board certified in Pediatric Surgery and General Surgery. Dr. Mychaliska’s practice encompasses all aspects of pediatric surgery. His clinical areas of interest and expertise are prenatal diagnosis and fetal surgery. Dr. Mychaliska’s research interests include prenatal diagnosis and therapy, pulmonary development, and congenital diaphragmatic hernia.[/vc_column_text][/vc_column][/vc_row]

Application of Human Amniotic Membrane in Tissue Engineering – Bo Wang, PhD @ Ob-Gyn Conference Room #252 (2nd floor Wisconsin Diagnostic Lab Building)
Sep 27 @ 12:00 pm – 1:00 pm

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Presented by

Bo Wang, PhD
Director – Tissue Regenerative Engineering Laboratory (TRE Lab)
Assistant Professor – Department of Biomedical Engineering, The Marquette University and Medical College of Wisconsin

About

Dr. Bo Wang, Director and Principal Investigator of the TRE Lab, received her PhD in Biomedical Engineering from Mississippi State University in 2012 and completed her Postdoctoral Fellowship at Northwestern University’s Feinberg School of Medicine, Department of Surgery, in 2016. She joined the Marquette-MCW Joint Department of Biomedical Engineering in January of 2019 with research interests that include stem cell engineering, hard-tissue engineering and 3D bioprinting, as well as vascular tissue engineering, imaging, modeling and simulation.

The Tissue Regenerative Engineering Laboratory is developing bio-functional engineered tissues that provide advanced therapeutic options for such conditions as birth defects, bone disorders, and liver and vascular diseases. To do this, the TRE Lab will first develop a greater understanding of the biological and molecular processes involved in regenerative regression.

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Oct
11
Wed
2023
2023 Eleanor Delfs Lecture: “Women’s Health from Molecule to Market” – Dr. Kelle Moley @ MCW Alumni Center
Oct 11 @ 8:30 am – 9:30 am

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Featured Speaker: Kelle Moley, MD – “Women’s Health from Molecule to Market”

Dr. Kelle Moley is a career physician-scientist obstetrician/gynecologist who currently leads the Reproductive Health Technologies Domain within the Discovery & Translational Sciences, Global Health Division at the Bill and Melinda Gates Foundation. Kelle joined BMGF in July 2020, with a 30-year history of basic and translational research on reproductive health issues in females throughout the life course– from organismal to cellular and molecular levels of metabolic, developmental biology, embryo implantation and decidualization, and infectious diseases of the female reproductive tract.

Kelle earned her BA from Wellesley College, and her MD from Yale Medical School. Thereafter, she pursued an Obstetrics & Gynecology Residency and a Fellowship in Reproductive Endocrinology & Fertility at Washington University in St. Louis School of Medicine. Kelle then spent the next 3 decades of a thriving research career at Washington University—rising to become the James P. Crane Professor of Obstetrics & Gynecology, Vice Chair of Obstetrics & Gynecology, Chief of the Division of Basic & Translational Research for the Department of Obstetrics & Gynecology, Co-Director of the Institute of Clinical & Translational Science for the School of Medicine, and Director of the Center for Reproductive Health Sciences at the School of Medicine. Her research (published in some 150 peer-reviewed primary articles) led to an international reputation along with numerous honors, including election to the National Academy of Medicine in 2014. She also earned a reputation as a superb mentor to trainees, leading the reproductive endocrinology fellowship program at Washington University until she left academia in 2018. After a 2-year stint as Chief Scientific Officer and Senior Vice President of the March of Dimes she left to pursue her new position at BMGF.
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Given the prestige of the endowed lecture as well as our guest, please plan to be in person for attendance. There will be a zoom link for hybrid participation for extenuating circumstances and to allow the largest diversity of participation from our campus guests.

Register via Zoom for those not able to attend in person.


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Mar
6
Wed
2024
“Advances Toward the Next Generation Tools For Precision Medicine” – Navonil De Sarkar, PhD @ Ob-Gyn Conference Room #252 (2nd floor Wisconsin Diagnostic Lab Building)
Mar 6 @ 12:10 pm – 1:10 pm

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Presented by

Navonil De Sarkar, PhD
Assistant Professor – Department of Pathology at the Medical College of Wisconsin

About

Navonil De Sarkar is an Assistant Professor at the Medical College of Wisconsin Cancer Center with a dual background in computational and experimental genomics; he brings a multidisciplinary approach to studying human cancers. His research focuses on understanding the natural history of the disease, devising noninvasive approaches to track adaptive and molecular evolutionary changes in cancer accurately, and ultimately developing practical strategies for precision medicine in advanced cancer patients (Augmented precision medicine).

Navonil received his Ph.D. from the Indian Statistical Institute and joined Peter Nelson’s lab at the University of Washington & Fred Hutchinson Cancer Research Center, Seattle, for postdoctoral training. Through adopting integrative genomics approaches, Navonil developed extensive experience analyzing tumor genomes to study functionally relevant mutations and structural aberrations using tumor tissue and circulating tumor DNA (ctDNA). Navonil participated in several large-scale consortium data analyses, including Stat-up-to-cancer germline and prostate tumor analysis efforts. Navonil led the bioinformatics analysis of the large-scale germline sequence work that highlighted the importance of inherited DNA repair genes in shaping the fate of advanced prostate cancer. He is one of the early discoverers of CDK12 loss-associated tandem duplicator signature. Subsequently, De Sarkar developed a machine learning-based classifier that accurately predicts functional homologous recombination deficiency. Recently, he co-led a study interrogating whole genomes of advanced prostate cancers using cell-free DNA sequencing and discovered imprints of cancer epigenomes in native cell-free DNA sequence data.

Navonil is a recipient of several trainee awards. To mention in 2019 Navonil received the very competitive Prostate Cancer Foundation Young Investigator Award. Then onwards, Navonil is co-leading Prostate Cancer Foundation DNA repair-focused working group activities. He is the editorial board member for Translational Oncology and an associate editor for the Genitourinary Oncology edition of Frontiers journals.

Navonil re-joined MCW in March 2023 and committed to establishing a multidisciplinary research group to develop cutting-edge but practical precision medicine tools for prostate and other cancers. Building on strong biological fundamentals and detailed understandings of the disease, De Sarkar Lab (DeTAnomics Lab) is developing novel therapeutic strategies and working to co-develop new genomic assays and computational genomics tools to help us tackle the most lethal types of prostate and other cancers. DeTAnomics Lab adopts long-read genomic sequencing techniques to better understand cancer genome, transcriptome, and epigenome. In the lab, DeTAnomics lab explores the complex interplay between the genome and epigenome to uncover new insights that can lead to the development of more effective therapeutics and biomarkers. Currently, DeSarkar and his team are working on developing a practical strategy to degrade BRCA2 in tumor cells so as to confer DNA-damaging mediated therapy benefits to a wider pool of patients.

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