Calendar of Events

May
28
Tue
2019
Link Between HPV and Cervical Cancer with Dr. Denise Uyar: CTSI Science Cafe @ St. Ann Center for Intergenerational Care (Bucyrus Campus)
May 28 @ 5:30 pm – 6:30 pm
Link Between HPV and Cervical Cancer with Dr. Denise Uyar: CTSI Science Cafe @ St. Ann Center for Intergenerational Care (Bucyrus Campus)

The next CTSI Science Café will be held on Tuesday, May 28, from 5:30 – 6:30 p.m. at St. Ann Center for Intergenerational Care (Bucyrus Campus), located at 2450 W. North Avenue in Milwaukee.

The May topic will be Examining the Link Between Human Papillomavirus (HPV) and Cervical Cancer. The discussion will be led by Denise Uyar, MD, associate professor of obstetrics and gynecology in the Froedtert & the Medical College of Wisconsin Cancer Center. The presentation will be followed by a community conversation on topic.

CTSI Science Café is free and open to the public by registering here. Light refreshments will be served.

For more information, please contact Angie Holtz, aholtz@mcw.edu or 414-955-2540.

May
29
Wed
2019
2019 Eleanor Delfs Lecture @ MCW HRC Auditorium
May 29 @ 9:00 am – 10:00 am

Featured Speaker: Nicholas Illsley, DPhil – “Epithelial-Mesenchymal Transition in Trophoblast: a Key Role in Normal and Pathological Pregnancies”

Nicholas P. Illsley, D.Phil

Senior Scientist
Department of Obstetrics and Gynecology
Hackensack University Medical Center
Adjunct Professor of Pharmacology, Physiology and Neuroscience
Rutgers-New Jersey Medical School

Dr. Illsley moved to Hackensack University Medical Center in 2012, following positions at the U.K. Medical Research Council’s Clinical Research Centre in London, the Department of Obstetrics, Gynecology and Reproductive Sciences at the University of California San Francisco and the Department of Obstetrics, Gynecology and Women’s Health at UMDNJ-New Jersey Medical School. His research focuses on the human placenta, its mechanisms of maternal to fetal transport, metabolism and role in the regulation of fetal growth. He has studied diabetic pregnancy, fetal growth restriction, preeclampsia and pregnancies subject to chronic hypoxia. He has published more than 80 articles in scientific journals on these topics. He has been awarded multiple research grants, primarily from the National Institutes of Health (NIH), with continuous funding since 1988. Dr. Illsley has been instrumental in developing and promoting the NIH Human Placenta Project, a 10-year effort to devise real-time methods for examining placental function.

Dr. Illsley is a leader in his field, helping to found both the Placenta Association of the Americas for which he served as the first President (2001-2011) and the International Federation of Placenta Associations for which he is completing a five-year term as President. He has served on several journal editorial boards and on the Council of the Society for Gynecologic Investigation and Perinatal Research Society. He was a charter member of the NIH Human Embryology and Development Study Section and continues to serve on multiple NIH study sections, reviewing research in perinatal medicine. Dr. Illsley has now put this experience and expertise to use in a new role, leading investigations for the Center for Abnormal Placentation. In collaboration with Dr. Zamudio and Dr. Al-Khan, he is developing new research to investigate the molecular biology that underlies placental invasion into the uterus in both normal and abnormal pregnancies. He is particularly interested in abnormally invasive placenta (placenta accreta) and preeclampsia.

Learn more about the Eleanor Delfs Lectureship for Pioneers

Jun
19
Wed
2019
2019 Resident and Fellow Research & Alumni Day @ Medical College of Wisconsin - Alumni Center
Jun 19 @ 7:00 am – 1:00 pm

Resident and Fellow Research and Alumni Day is an annual event where our residents and graduating fellow present their clinical, translational science, and educational research results within their residency and fellowship in the Department of Obstetrics and Gynecology.

The Roland S. Cron Lectureship

Guest Speaker

William M. Leininger, MD, FACOG – “Advocacy Beyond the Statehouse”
Assistant Professor, Uniformed Services University of the Health Sciences
Fellow, Physicians for Reproductive Health

About Dr. Leininger

Dr. William M. Leininger, MD, FACOG (CAPT, MC, USN [Ret]), currently practices as a board certified, Obstetrician/Gynecologist at Naval Medical Center San Diego (NMCSD). He served on the hospital’s Graduate Medical Education Executive Committee, and is an Assistant Professor of Obstetrics and Gynecology at the Uniformed Services University of Health Sciences, Bethesda, MD. He has previously served as the Obstetrics and Gynecology Specialty Advisor to the Surgeon General of the Navy (2012-2015), and was a Residency Program Director for Obstetrics and Gynecology at Naval Medical Center San Diego (2007-2012).

Dr. Leininger graduated from Williams College with a BA in Biology in 1986, and then spent a year teaching high school math and science at the Landon School in Bethesda, MD (his alma mater). He next attended the University of Cincinnati College of Medicine and graduated in 1991, and subsequently completed his residency training in Obstetrics and Gynecology at NMCSD in 1997. In addition to San Diego, he practiced at the Naval hospitals in Bethesda, MD, Portsmouth, VA, Camp Pendleton, CA, and Keflavik, Iceland.

During his 26 years in the Navy, he deployed to the Persian Gulf and Kuwait, and served in humanitarian operations in Somalia (Operation Restore Hope), Guatemala, and Indonesia (Operation Tsunami Relief). During his career, he also worked on numerous policy issues, patient safety strategies, and medical education improvements, covering topics such as updates to the armed services’ abortion policy, developing care guidelines for transgender service personnel, decreasing cesarean section rates, preventing unplanned pregnancies, delivering healthcare for pregnant and deployed servicewomen, and promoting the core competency of professionalism.

Dr. Leininger is married to a Marine Corps veteran and a former volunteer fire fighter, and his wife is now a Senior GIS Analyst/Cartographer for the North County Dispatch JPA, providing support to the Fire and EMS Services in northern San Diego County. They live in Escondido, CA, and have three rescued German Shepherds.

Agenda

TimeActivity
7:00amREGISTRATION & BREAKFAST
7:45amWELCOME
8:00amAmanda Johnson, MD, MFM Fellow
“Altered neural calcium signaling in HCMV infection is mitigated with viral kinase inhibition”
Mentor: Scott Terhune, PhD
8:15amKathryn Carnahan, MD, R3
Association Between Continuity of Care and Health Care Utilization in an OB/GYN Resident Clinic
Mentor: Jessica Francis, MD
8:30amTalia Coney, MD, R3
Maternal Outcomes of Pregnancies Complicated by Life-Limiting Conditions
Mentor: Anna Palatnik, MD
8:45amJustin Harold, MD, R3
“All That Glitters isn’t Node: Failed Sentinel Lymph Node Mapping with Indocyanine Green in Women with Endometrial Cancer”
Mentor: William Bradley, MD
9:00amBREAK
9:15amSarah Hirsch, DO R3
Desire for Psychosocial Support and Barriers to Counseling in Couples with Infertility
Mentor: Abbey Kruper, PsyD
9:30amIsabel Nellen, DO, R3
Adiponectic in Visceral and Omental Fat in Middle Aged Women with a History of Infertility
Mentor: Kate Schoyer, MD
9:45amCindy Vu, MD, R3
Medical Students and the Influence of Gender in Obstetrics and Gynecology Education: A Possible Case of Gender-Bias?
Mentor: Rahmouna Farez, MD & Kristina Kaljo, PhD
10:00amBREAK
10:15amThe Roland S. Cron Lecture: William Leininger, MD, FACOG
“Advocacy Beyond the Statehouse”
11:30pmLUNCH

Learn More about Resident and Fellow Research & Alumni Day

Sep
11
Wed
2019
2019 Annual Sterner Lecture for Fetal Medicine @ MCW HRC Bolger Auditorium
Sep 11 @ 9:00 am – 10:00 am

Featured Speaker: Stephen P. Emery MD, FACOG – “Ventriculoamniotic Shunting for Fetal Aqueductal Stenosis”

Stephen P. Emery MD, FACOG

Associate Professor, Department of Obstetrics, Gynecology, & Reproductive Sciences, Divisions of Ultrasound and Maternal-Fetal Medicine
Director, Center for Innovative Fetal Intervention at Magee-Womens Hospital of UPMC
University of Pittsburgh School of Medicine

Dr. Emery is the Director of the Center for Innovative Fetal Intervention at Magee-Womens Hospital of UPMC. He is the principal provider of fetal therapy for this geographic region. He is the main instructor on fetal therapy for Maternal-Fetal Medicine fellows, Ob/Gyn residents and medical students. Dr. Emery is the Chair of the Steering Committee of the North American Fetal Therapy Network (NAFTNet) and is responsible for its research agenda. He has recently conducted a multinational, multicenter, multidisciplinary study on the treatment of early-stage twin-twin transfusion syndrome (TTTS) which was published in a major medical journal and presented ant the 36th International Fetal Medicine and Surgery Society (IFMSS) meeting in August of 2016. Dr. Emery is leading an international evidence-based reassessment of ventriculoamniotic shunting for fetal severe hydrocephalus through NAFTNet and IFMSS. His clinical, research and education efforts revolve around fetal therapy.

Sep
18
Wed
2019
Role of Vascular Smooth Muscle RhoBTB1/Cullin-3 in Hy-pertension: A Role in Preeclampsia? – Curt Sigmund, PhD @ Ob-Gyn Conference Room #252 (2nd floor Wisconsin Diagnostic Lab Building)
Sep 18 @ 12:00 pm – 1:00 pm

Presented by

Curt D. Sigmund, PhD

Curt D. Sigmund, PhD
James J. Smith & Catherine Welsch Smith Professor and Chair, Department of Physiology
Associate Director, Cardiovascular Center
Medical College of Wisconsin

Dr. Sigmund’s Research

Dr. Sigmund’s major areas of research focus on central nervous system and vascular mechanisms of blood pressure regulation by the renin-angiotensin system, the transcription factor PPAR-gamma, and its downstream effectors Cullin-3/RhoBTB1, investigating these using a combination of molecular biological, genetic and physiological approaches including the generation of unique transgenic and knockout models. Dr. Sigmund’s laboratory is located within the Cardiovascular Center in the Health Research Center and Medical Education buildings.

Learn more about the WHRP Seminars

Sep
25
Wed
2019
2019 E. James Aiman Lecture @ Medical College of Wisconsin - HRC Auditorium
Sep 25 @ 8:30 am – 9:30 am

Featured Speaker: Gregg Nelson, MD, PhD – “ERAS – The New Standard of Surgical Care in Obstetrics & Gynecology”

Gregory S. Nelson, MD, PhD

Professor and Chair, Division of Gynecologic Oncology, University of Calgary, Tom Baker Cancer Centre

About Dr. Nelson

Dr. Gregg Nelson obtained his MD and PhD degrees at the University of Calgary in Calgary, Alberta, Canada and subsequently continued on to complete his sub-specialization in Gynecologic Oncology at the Tom Baker Cancer Centre. He joined the Section of Gynecologic Oncology at TBCC in July 2010, and was the local Gyn Tumour Team lead and Chair of the Provincial Gynecologic Oncology Tumour Team from 2011-2018. He is currently Chair of Gynecologic Oncology and is Professor in the Departments of Obstetrics & Gynecology and Oncology at the Cumming School of Medicine.

Dr. Nelson’s principal research interests are the development and study of enhanced recovery protocols in cancer surgery and interventions to improve HPV vaccination in First Nations populations. He holds the position of Surgical Lead, ERAS Alberta and he also leads the international group that published the ERAS® Guidelines for Gynecologic/Oncology Surgery. Recently he has been appointed the Secretary of the ERAS® Society Executive Committee based in Sweden. He leads the EHVINA study – Enhancing HPV Vaccination In First Nations Populations in Alberta – a $1,250,000 project funded by Alberta Innovates/Alberta Cancer Prevention Legacy Fund.

Dr. Nelson has over 100 peer-reviewed publications and has presented numerous times internationally. He currently serves on the Editorial Board of the International Journal of Gynecological Cancer.

Learn more about the E. James Aiman, MD, Endowed Lectureship

Sep
30
Mon
2019
Uterine Fibroids: Drs. Benjamin Beran and Alexandra Fairchild, MD @ Froedtert Community Conference Center, Room 1
Sep 30 @ 6:00 pm – 7:00 pm

Finding accurate information about fibroids can be difficult especially in regards to diagnosis and treatment. Dr. Beran and Dr. Fairchild have teamed together to offer a collaborative clinic for consulting on challenging cases of uterine fibroids. This class will provide a better understanding of uterine fibroids highlighted by a thorough review of treatment options.

Presentation by: Benjamin Beran, MD, and Alexandra Fairchild, MD.

Register online by going to Froedtert Health’s Classes and Events

Oct
3
Thu
2019
What’s in an Annual? – Amy Domeyer-Klenske, MD @ Moorland Reserve Health Center
Oct 3 @ 6:00 pm – 7:00 pm

What’s in an Annual? The Who, What, When and Why of Preventative Gynecology Care. Learn about the new advances, changes and recommended screenings in women’s health.

Presentation by: Amy Domeyer-Klenske, MD.

Register

Oct
16
Wed
2019
Diagnosing and Treating Preeclampsia: What Does The Brain and Urine Have To Do With It? – Mark Santillan, MD, PhD, FACOG, FAHA @ Ob-Gyn Conference Room #252 (2nd floor Wisconsin Diagnostic Lab Building)
Oct 16 @ 12:00 pm – 1:00 pm

Presented by

Mark Santillan, MD, PhD, FACOG, FAHA

Mark Santillan, MD, PhD, FACOG, FAHA
Assistant Professor of Obstetrics and Gynecology – Maternal Fetal Medicine
Faculty, Molecular and Cellular Biology
Clinical Research Director, Maternal Fetal Tissue Bank
Co-Director, OB/GYN Residency Research
Carver College of Medicine

Dr. Santillan’s Research

The Santillan lab is particularly interested in the relationship between maternal health during pregnancy and the short and long-term health effects to the mother and child. Specifically, our current work focuses on the early mechanisms involved in the development of preeclampsia, including immunological and vascular function changes during pregnancy. A central focus in the lab is investigating the predictive, preventative, therapeutic and curative potential of the arginine vasopressin pathway in preeclampsia. Leveraging the group’s novel discovery of a very early biomarker for preeclampsia and a novel mouse model for preeclampsia, our lab works to investigate the mechanistic underpinnings of the predictive and therapeutic potential of vasopressin in the management of preeclampsia in a translational manner. As a practicing academic high-risk obstetrician, Dr. Santillan is very qualified in caring for women with high risk pregnancies, in understanding their clinical management, and in conducting clinical/translational research in perinatal biology. He has been successful in conducting studies in both murine and human pregnancies. As the clinical research director and co-founder of the Maternal Fetal Tissue Bank, Dr. Santillan has significant experience in clinical data acquisition, management, and analysis as well as molecular biology techniques needed for translational studies. Furthermore, as the Principal Investigator of the Population project of the University of Iowa American Heart Association Strategically Focused Research Network in Hypertension, Dr. Santillan has developed the PREDICTV network of prenatal providers around the state of Iowa to collect samples and clinical information from a diverse cohort of pregnant women.

Learn more about the WHRP Seminars

Oct
28
Mon
2019
Endometriosis: Benjamin Beran, MD and Camila Bomtempo, MD @ Froedtert Community Conference Center, Room 1
Oct 28 @ 6:00 pm – 7:00 pm
Endometriosis: Benjamin Beran, MD and Camila Bomtempo, MD @ Froedtert Community Conference Center, Room 1

Endometriosis typically presents with painful periods, painful intercourse, chronic pelvic pain or infertility. Despite being a common finding, a lot of misinformation exists on endometriosis. Gain a better understanding of endometriosis through accurate medical information.

Presentation by: Benjamin Beran, MD, and Camila Bomtempo, MD.

Register online by going to Froedtert Health’s Classes and Events

Nov
12
Tue
2019
Breastfeeding: Beyond the Basics with Sarah Mess, CNM @ Moorland Reserve Health Center
Nov 12 @ 6:00 pm – 7:00 pm

When significant breastfeeding challenges are expected or met, creating a plan ahead of time can reduce stress and improve the breastfeeding experience

Presentation by: Sarah Mess, CNM.

Register online by going to Froedtert Health’s Classes and Events

Nov
13
Wed
2019
Developing Novel Biomarkers and Therapies Against Ovarian Cancer – Manish Patankar, PhD @ Ob-Gyn Conference Room #252 (2nd floor Wisconsin Diagnostic Lab Building)
Nov 13 @ 12:00 pm – 1:00 pm

Presented by

Manish Patankar, PhD
Professor, Obstetrics & Gynecology, Division of Reproductive Sciences
Associate Director, Endocrine and Reproductive Physiology (ERP) Program
University of Wisconsin-Madison, School of Medicine and Public Health

About

Dr. Manish Patankar is a Professor in the Division of Reproductive Sciences. Dr. Patankar grew up in Thane, India, a city that borders Mumbai (Bombay). His wife is a physical therapist at the American Family Children’s Hospital and they have a 7 year old daughter who is in first grade at Glenn Stephens Elementary.

Dr. Patankar graduated from the University of Bombay, India with a B.S. in Chemistry in 1987. Subsequently, he received his Masters of Science in Organic Chemistry from the University of Bombay in 1990, and his Masters of Chemistry from Old Dominion University in Norfolk, Virginia in 1993. Dr. Patankar then completed his PhD in Biomedical Sciences at Eastern Virginia Medical School/Old Dominion University in 1998.

Dr. Patankar was an instructor and Research Professor at Eastern Virginia Medical School until 2004 when he joined the department as Professor and also became a member of the UW-Madison Carbone Cancer Center. His current research includes developing diagnostic tests for ovarian cancer and preeclampsia and strategies for treating ovarian cancer.

Collaborations at UW-Madison include: Drs. Joseph Connor, David Abbott, Paul Sondel, David Beebe, Ralph Albrecht, Mark Cook, Sean Fain, Ian Rowland, Hirak Basu and and Lingjun Li. Non UW-Madison collaborations include: Drs. Mitchell Ho and Ira Pastan (National Cancer Institute), Dr. Jennifer Gubbels (Augustana College, SD), Rebecca Whelan (Oberlin College, OH), Biotech Industry: Neoclone Biotechnology (Madison), and Gentel Biosciences (Fitchburg).

Dr. Patankar teaches Endocrine Physiology, Biology 151, and lectures on immunology in several different courses on campus.

What does he do in this spare time? He loves music and watching SpongeBob with his daughter.

One of the most interesting places that Dr. Patankar has visited is Bergen, Norway.

Research Focus

The primary focus of my research is to devise specific methods for early diagnosis of epithelial ovarian cancer (EOC) and to understand the effect of factors produced by ovarian tumors on the functional capacity of tumor infiltrating lymphocytes. This research involves extensive utilization of glycoproteomic analysis in conjunction with cellular immunology, molecular biology and glycobiology.

Learn more about the WHRP Seminars

Dec
12
Thu
2019
Anxiety in Women: Healthy Ways to Respond with Abbey Kruper, PsyD @ Froedtert Menomonee Falls Hospital
Dec 12 @ 6:00 pm – 7:00 pm

Learn basic information about how anxiety can present in women and develop strategies to manage distress in order to have a fuller life.

Presentation by: Abbey Kruper, PsyD, psychologist

Register Online

Register online through the link to Froedtert’s classes and events below.

Dec
18
Wed
2019
Investigating Sugars and Artificial Sweeteners Exposure in Pregnancy and Lactation – Stephanie Olivier-Van Stichelen, PhD @ Ob-Gyn Conference Room #252 (2nd floor Wisconsin Diagnostic Lab Building)
Dec 18 @ 12:00 pm – 1:00 pm

Presented by

Stephanie Olivier-Van Stichelen, PhD
Assistant Professor, Biochemistry
Medical College of Wisconsin

About

Dr. Olivier-Van Stichelen received her PhD degree in Biochemistry from the University of Lille, France in 2012. Her work was focused on the understanding of the nutrient-sensing O-GlcNAcylation in colorectal cancer development with a special interest in diet-dependent modification of the oncogene beta-catenin.

After completion of her degree, she was appointed as a post-doctoral Fellow in the Laboratory of Cellular and Molecular Biology at the National Institute of Health, Bethesda, MD, USA. In this lab, Dr. Olivier-Van Stichelen worked on different aspects of O-GlcNAcylation during development including X-inactivation of the O-GlcNAc Transferase gene. She also developed a brain O-GlcNAcase knockout model and studied the impact of sugar consumption during pregnancy on O-GlcNAc-dependent development of metabolic homeostasis. More recently, she developed interests in understanding the importance of artificial sweeteners for offspring’s metabolism and microbiome.

Dr. Olivier-Van Stichelen established her lab at the Medical College of Wisconsin at the crossroad of sweeteners, pregnancy, development and metabolism.

Research Focus

Due to the global trend of growing sweetener consumption, determining the interplay between diet and pre- and post-natal development is emerging as a critical area for research. Currently, the average American eats around 22 teaspoons of added sugar every day (30 sugar cubes/day hidden in foods). This modern glucose-rich diet correlates with an increase in the prevalence of obesity, diabetes and others metabolic syndromes. Moreover, the effort to reduce sugar consumption has led people to consume more non-caloric sweeteners (Aspartame, Sucralose, Acesulfame-K…). While they appear healthier for glucose homeostasis than a high carbohydrate diet, recent studies have shown that artificial sweeteners impact glucose metabolism as well as gut microbiota, rising questions about their excessive use.

Therefore, understanding what happens when caloric and non-caloric sweeteners are metabolized is of utmost importance for public health and the focus of my research group.

Nutrient-dependent O-GlcNAc cycling in development and disease

O-GlcNAcylation is one of the key components of diet-responsive signaling. This unique glucose rheostat is a ubiquitous and dynamic glycosylation of intracellular proteins with approximately 1000 modified proteins described to date. Two key enzymes drive O-GlcNAc cycling: The O-GlcNAc transferase (OGT) adds the modification and the O-GlcNAcase (OGA) removes it. Although many studies have focused on the decrease or complete absence of O-GlcNAc cycling by modulating the expression or activity of OGT, only a few studies have targeted hyper-O-GlcNAcylation by disturbing OGA. Because this post-translational modification is directly dependent on glucose input, depleting OGA creates an artificial and constant hyperglycemia-induced O-GlcNAcylation state. Using Oga and Ogt knockout (KO) cellular and mouse models, we can decipher the impact of high carbohydrate diet on embryonic development.

Non-Nutritive Sweeteners in pregnancy and lactation

Part of my lab is interested in understanding the impact of Non-Nutritive Sweetener (NNS) consumption through pregnancy and lactation. Although, NNS have been found in mother’s milk and in placental blood circulation, no study has focused on the fundamental effect of those non-caloric sweeteners on the developing organism.

Among the impacts described in adults are changes in intestinal hormonal secretion, glucose metabolism and most fascinating, re- duction of the gut microbiota. Nevertheless, the fundamental mechanisms of those changes are far from understood. Glycoproteins found on the surface of the intestinal epithelium define the glycocalyx and are an essential mammalian mechanism of communication with the gut microbiome. Their reciprocal relationship with the gut microbiome regulates not only nutrient breakdown, and food absorption, but also infection. We are convinced that by altering both microbiome and the detoxification process, NNS exposure in early life will impact metabolic homeostasis later in life.

Learn more about the WHRP Seminars

Jan
15
Wed
2020
Alcohol-Induced Developmental Brain Injury – Xiaowen Bai, MD, PhD @ Ob-Gyn Conference Room #252 (2nd floor Wisconsin Diagnostic Lab Building)
Jan 15 @ 12:00 pm – 1:00 pm

Presented by

Xiaowen Bai, MD, PhD

Xiaowen Bai, MD, PhD

Xiaowen Bai, MD, PhD
Associate Professor, Cell Biology, Neurobiology & Anatomy
Medical College of Wisconsin

About

Dr. Bai’s research interests are centered on the application of stem cells on disease modeling and tissue regeneration. The current major focus of the laboratory is to utilize gain- and loss-of-function approaches to examine the novel molecular mechanisms underlying the roles of non-coding RNAs, mitochondria, and genetic factors in neurodegeneration and cardiotoxicity in mice, and translate the findings to humans using stem cell-derived brain cells, heart cells, three-dimensional mini brains, and heart organoids.

Research Area 1:

Non-coding RNAs, mitochondria, and cell stress-related genes in neurodegeneration:
Neurological disorders have emerged as a predominant healthcare concern in recent years due to their severe consequences on quality of life and prevalence throughout the world. Understanding the underlying mechanisms of these diseases and the interactions between different brain cell types is essential for the development of new therapeutics. Many drugs (e.g., anesthetics), environmental factors (e.g., alcohol), diseases, and genetic risks are related to neurodegeneration. We examine the novel molecular mechanisms underlying the roles of microRNAs, long non-coding RNAs, mitochondria, immediate early and other cell stress-related genes in neurodegeneration using both mouse, and human stem cell-derived brain cell and three-dimensional mini brain models

Research Area 2:

Stem cell-mediated myocardial regeneration
Myocardial infarction is one of the major causes of death throughout the world. Currently, there is not a highly effective approach for treatment. Stem cells hold promise in repairing injured cardiac tissue. Our lab is involved in studying the effect of the transplantation of adipose tissue-derived stem cells and induced pluripotent stem cell-derived cardiomyocytes on myocardial regeneration following ischemia injury. A molecular imaging method has been developed to investigate the molecular mechanisms controlling homing, engraftment, and survival of injected cells in vivo.

Research Area 3:

The mechanisms of impaired cardioprotection under diabetic conditions
Hyperglycemia has been shown to be particularly detrimental to the cardioprotective effects, with the underlying mechanisms remaining largely unknown. We have developed and validated a clinically relevant model of functional human cardiomyocytes derived from both normal induced pluripotent stem cells (iPSCs) and diabetes mellitus iPSCs. This in vitro model of human disease will enable developmental and comparative studies of normal and diabetic cardiomyocytes to address genetic and environmental mechanisms responsible for attenuation of cardioprotection signaling in diabetics.

Learn more about the WHRP Seminars

Feb
3
Mon
2020
Taking Control of Your Bladder with Emily Davidson, MD @ Froedtert Fitness Center, Wauwatosa
Feb 3 @ 6:00 pm – 7:00 pm

Urinary issues including urgency and leakage are not something you should have to live with or schedule your life around. Learn about types of leakage and the options that exist for treatment.

Presentation by: Emily Davidson, MD, Urogynecologist

Register Online

Register online through the link to Froedtert’s classes and events below.

Feb
6
Thu
2020
Does My Diet Affect Getting Pregnant? with Carol Eling, APNP @ Froedtert Drexel Town Square Health Center
Feb 6 @ 6:00 pm – 7:00 pm

We will take a look at the latest research on reproductive nutrition to improve your chances of conceiving.

Presentation by: Carol A. Eling, Advanced Practice Nurse Practitioner

Register Online

Register online through the link to Froedtert’s classes and events below.

Feb
19
Wed
2020
Analysis of Collagen Alterations in Human Ovarian Cancer by High Resolution Optical Microscopy – Paul Campagnola, PhD @ Ob-Gyn Conference Room #252 (2nd floor Wisconsin Diagnostic Lab Building)
Feb 19 @ 12:00 pm – 1:00 pm

Presented by

Paul Campagnola, PhD
Professor, Biomedical Engineering
University of Wisconsin-Madison

About

Campagnola’s research is directed toward developing high resolution imaging modalities. The technologies his group has developed can readily be applied to problems in eye and vision research. For example, the technique of Second Harmonic Generation (SHG) to image collagen fibrillar structure has been used by other labs to image the corneal structure. Expanding into eye research is a natural direction for the Campagnola Laboratory.

Alterations to the extracellular matrix (ECM) composition and structure are thought to be critical for tumor initiation and progression for several epithelial carcinomas, including those of the ovary and breast. Our lab develops Second Harmonic Generation (SHG) microscopy tools to quantitative assess these alterations in the stroma where we correlate the optical signatures with structural changes in the fibrillar assembly between normal and diseased tissues. This physical approach provides objective measurements that may be used to understand disease progression. To further investigate how remodeling enables invasion and metastasis in vivo we use multiphoton excited (MPE) photochemistry to fabricate biomimetic in vitro models of the ovarian ECM. The nano/microstructured models simulate the crosslinked fibrillar structure of the native ECM.

Tissue engineering has vast potential to improve human health by repair and maintenance of existing tissue or generation of replacement of tissues and organs. A major limitation has been an incomplete understanding of the underlying cell-ECM interactions that govern cell adhesion which will ultimately affect downstream functions. Our approach to this problem utilizes MPE photochemistry to create 3D biomimetic scaffolds directly from crosslinked proteins. Beginning with bio-inspired designs we will seek to achieve improved function.

Learn more about the WHRP Seminars

May
1
Fri
2020
Blood, Sweat and Tears – The Challenges of Hematologic Disorders in Pregnancy with Jennifer McIntosh, DO, MS @ Virtual WebEx - email below for link
May 1 @ 8:00 am – 9:00 am
May
13
Wed
2020
Professional Development Series – Early Career Financial Planning- Chief School and Faculty Development @ Virtual Invite via Outlook
May 13 @ 9:30 am – 11:00 am
Professional Development Series - Early Career Financial Planning- Chief School and Faculty Development @ Virtual Invite via Outlook

The Department of Obstetrics & Gynecology invites you to our 2019-2020 Professional Development Series: May 13th

We would like to invite you to a joint session for our graduating chiefs and early physician/faculty on financial planning in the early physician career. 2 financial advisors from the Fortress Planning Group have donated their time to provide a session on financial planning for the early-career physician and will have time to answer questions. I hope you’ll join us! Concomitant educational sessions will be recorded.

May
20
Wed
2020
Professional Development Series – Faculty Promotional Portfolio – Jennifer Apps, PhD, May 20th @ Virtual Invite via Outlook
May 20 @ 8:00 am – 9:00 am

The Department of Obstetrics & Gynecology invites you to our 2019-2020 Professional Development Series: May 20th

Guest Speaker:

Jennifer Apps, PhD
Assistant Dean of Faculty Affairs
Associate Professor, Pediatrics

Please join us for a session with Dr. Jennifer Apps on portfolio creation and development for promotion. This session will review the current state of the professional portfolio at MCW. Please come prepared to make some notes as we explore existing tools you can utilize to support your own portfolio creation. You will be able to begin outlining your plan for creating and managing your portfolio.

Jun
24
Wed
2020
2020 Resident and Fellow Research & Alumni Day @ Virtual Session: Register below for link
Jun 24 @ 7:45 am – 11:00 am
2020 Resident and Fellow Research & Alumni Day @ Virtual Session: Register below for link

Resident and Fellow Research and Alumni Day is an annual event where our residents and graduating fellow present their clinical, translational science, and educational research results within their residency and fellowship in the Department of Obstetrics and Gynecology.

Due to COVID-19, this event will be virtual. Register with the link below to receive the Webex information.

REGISTER

Agenda

TimeActivity
7:45amWELCOME
8:00amRachel Harrison, MD, MFM Fellow
Fibroblast Growth Factor 21 Placental Levels in Infants with Macrosomia

Mentors: Meredith Cruz, MD & John Corbett, PhD
8:15amPrecious Gaddis, MD, R4
The Prevalence and Impact of the Treatment of Vitamin D Deficiency in Patients undergoing In Vitro Fertilization

Mentor: Jayme Bosler, MD
8:30amBrian Tillis, MD, R4
Effect of a Best-Practice Alert on the Rate of Smoking Cessation
among Pregnant Women


Mentor: Anna Palatnik, MD
8:45amBradley Corbin, MD, R3
Enhanced Recovery After Surgery (ERAS) Protocols: Preoperative Education: Patient Satisfaction Outcomes

Mentor: Denise Uyar, MD
9:00amSpencer Gantz, MD, R3
Obstetric Outcomes in Pregnancies Complicated by Maternal Congenital Heart Disease

Mentor: Erika Peterson, MD
BREAK
9:15amColin Johnson, MD, R3
Assessment of the Immunologic and Clinical Significance of the Variable Microsatellite Instability Phenotype Observed in MMR-Deficient Endometrial Cancer

Mentor: William Bradley, MD
9:30amLauren Kurtz, MD, R3
Comparison of Hypertensive Disorder of Pregnancy Prevalence in Patients with Anxiety and Depression with or Without the Use of Psychotropic Medication

Mentor: Anna Palatnik, MD
9:45amTheresa Piquette, MD, R3
Obesity and Embryodynamics: Effect of BMI on Embryo Division Timing in Patients Undergoing IVF

Mentor: Kate Schoyer, MD
10:00amAshley Verhasselt, MD R3
Attitudes, Barriers and Needs of Healthcare Providers Providing Breastfeeding Support at Froedtert Hospital Birth Center

Mentors: Kristina Kaljo, PhD & Kate Dielentheis, MD
10:15amKate Wlodarczyk, MD
Neonatal Outcomes and Frequency of Ultrasound in Women with Prior Bariatric Surgery

Mentors: Meredith Cruz, MD & Rachel Harrison, MD
Jun
26
Fri
2020
2020 Resident and Fellow Graduation @ Virtual: Webex link below
Jun 26 @ 7:30 pm – 11:30 pm

[vc_row css_animation=”” row_type=”row” use_row_as_full_screen_section=”no” type=”full_width” angled_section=”no” text_align=”left” background_image_as_pattern=”without_pattern”][vc_column][vc_column_text]Please join us virtually to celebrate our 2020 Resident and Fellow Graduates

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2020 Resident Graduates

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Kathryn Carnahan, MD

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Talia Coney, MD

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Precious Gaddis, MD

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Justin Harold, MD

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Sarah Hirsch, DO

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Isabel Nellen, DO

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Brian Tillis, MD

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Cindy Vu, MD

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2020 Maternal-Fetal Medicine Fellowship

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Rachel Harrison, MD

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Aug
7
Fri
2020
Student-Centered Pipeline to Advance Research in Cancer Careers (SPARCC) Cancer Research Summit and Graduation @ Virtual Event
Aug 7 @ 10:30 am – 12:00 pm

Please join the Department of Obstetrics and Gynecology for the Student-Centered Pipeline to Advance Research in Cancer Careers (SPARCC) Cancer Research Summit and graduation on August 7, 2020, from 10:30 a.m.-12 p.m. This will be a virtual event, where the scholars will have the opportunity to share their research and open it up for questions and brief discussions for each presentation. We will conclude the event by “presenting” graduation certificates and acknowledging each scholar’s participation this summer.

Program:

10:30-11:30 a.m.: Research Presentations – Topics are centered on “wicked problems” found in cancer-specific research.

11:30 a.m.-12 p.m.: Graduation Ceremony – SPARCC Co-Directors Janet Rader, MD, and Kristina Kaljo, PhD, will present each of the scholars with a certificate of completion.

If you would like to attend, please email us at sparcc@mcw.edu.

SPARCC is an intensive 8-week summer program that immerses undergraduate students from backgrounds underrepresented in biomedical research in the complexities of clinical cancer research. To learn more, please visit obgyn.mcw.edu/sparcc.

Nov
9
Mon
2020
Family History in Cancer Screening and Treatment – Elizabeth Hopp, MD @ Virtual
Nov 9 @ 5:45 pm – 7:00 pm


Please join us virtually. This talk will detail what constitutes a significant family history along with discussion of genetic testing. The talk will also touch on management of hereditary cancer syndromes, such as Lynch syndrome and BRCA.

Presentation by: Elizabeth Hopp, MD, Gynecologic Oncologist

Register Online

Register online through the link to Froedtert’s classes and events below.

Nov
10
Tue
2020
Anxiety in Women: Healthy Ways to Respond with Abbey Kruper, PsyD @ Virtual
Nov 10 @ 5:45 pm – 7:00 pm

Please join us virtually to learn basic information about how anxiety can present in women and develop strategies to manage distress in order to have a fuller life.

Presentation by: Abbey Kruper, PsyD, psychologist

Register Online

Register online through the link to Froedtert’s classes and events below.

Nov
18
Wed
2020
Professional Development Series – Can We Talk? Emotionally Intelligent Feedback Conversations – Natalie Fleury, JD , November 18th @ Virtual Invite via Outlook
Nov 18 @ 9:30 am – 11:00 am

The Department of Obstetrics & Gynecology invites you to our 2020-2021 Professional Development Series

Guest Speaker:

Natalie Fleury, JD
Ombuds Office

Please join us for a session with Natalie Fleury, JD from the Ombuds office talking to us about Emotionally Intelligent Feedback Conversations.

Infertility: Fact or Fiction with Bo Rydze, MD @ Virtual
Nov 18 @ 5:45 pm – 7:00 pm


Please join us virtually! This talk is geared towards giving both individuals and couples the knowledge to make informed decisions about how to best go about building their families or preserving their fertility. During this time we will dispel common myths surrounding fertility and answer any questions you may have. We will also cover red flags that could mean a potential risk for infertility down the road.

Presentation by: Bo Rydze, MD, Reproductive Endocrinologist

Register Online

Register online through the link to Froedtert’s classes and events below.

Dec
9
Wed
2020
How Does Preeclampsia Impact Your Pregnancy and Your Future Health with Jennifer Jury McIntosh, DO @ Virtual
Dec 9 @ 5:45 pm – 7:00 pm


Please join us virtually! We will discuss what preeclampsia is and the signs and symptoms to watch for in pregnancy, as well as how it’s managed.

We will also explain the impact of preeclampsia on a woman’s future heart health.

Presentation by: Jennifer Jury McIntosh, DO, Perinatologist

Register Online

Register online through the link to Froedtert’s classes and events below.

May
13
Thu
2021
Autoimmune Disorders and Fertility with Jayme Bosler, MD @ Virtual Event (register below)
May 13 @ 6:00 pm – 7:00 pm

Please join us virtually! Women with existing autoimmune diseases may be at higher risk of infertility and some autoimmune conditions can increase a woman’s risk of miscarriage.

Together we will discuss these conditions and what to do to increase your chances of a successful pregnancy.

We will also explain the impact of preeclampsia on a woman’s future heart health.

Presentation by: Jayme Bosler, MD, Reproductive Endocrinology and Infertility physician

Register Online

Register online through the link to Froedtert’s classes and events below.

May
19
Wed
2021
Patient Education Webinar: Urinary Incontinence with Dr. Emily Davidson @ Virtual Event (register below)
May 19 @ 12:00 pm – 1:00 pm

Urinary issues including urgency and leakage are not something you should have to live with or schedule your life around. Learn about types of leakage and the options that exist for treatment.

Presentation by: Emily Davidson, MD, Urogynecologist

Sep
11
Sat
2021
Black Birth: A Maternal Health Conversation and Resource Fair @ Wisconsin Black Historical Society
Sep 11 @ 11:00 am – 1:00 pm


The Milwaukee Film Festival and Froedtert & the Medical College of Wisconsin present Black Birth: A Maternal Health Conversation and Resource Fair.

The short film Black Birth serves as the backdrop to a community dialogue about the joys, fears, complexities, and disparities of Black motherhood in America and locally in Milwaukee. Following the film screening will be a panel discussion including an OB-GYN physician and resident, community doula, African American breastfeeding expert, and other maternal-fetal care specialists, as well as a resource fair featuring leading health and wellness community partners.


This in-person event is FREE and open to the public. Space is limited to the first 150 people. Masks are REQUIRED and will be provided if needed. There is no virtual option. No Tickets required.

TimeTopic
11:00 AMWelcome and Introduction
11:15 AMShort Film
11:45 AM Discussion
12:15 - 1:00 PMPanel Questions and Discussion

Panelists

  • Moderator: Amy Domeyer-Klenske, MD – Obstetrician and Gynecologist
  • OBGYN Providers: Seema Menon, MD – Obstetrician and Gynecologist and Ciera Oshodi, MD – OBGYN Resident
  • Breastfeeding Expert: Dalvery Blackwell, BA, IBCLC with the African American Breastfeeding Network I
  • Doula
  • Patient
Sep
25
Sat
2021
Ray of Hope 5K Run/ 2K Walk for Ovarian Cancer Research (in person race with virtual option) @ Hoyt Park 1800 N Swan Blvd Wauwatosa, WI US 53226
Sep 25 @ 9:00 am – 12:00 pm
Ray of Hope 5K Run/ 2K Walk for Ovarian Cancer Research (in person race with virtual option) @ Hoyt Park 1800 N Swan Blvd Wauwatosa, WI US 53226

Join us September 25th for the Ray of Hope’s 3rd Annual Race! Help us run or walk to raise funds for ovarian cancer. All proceeds go directly to our researchers working hard to identify novel targets and treatment strategies to cure ovarian cancer.

Ray of Hope is a non-profit organization established in 2018 in the Greater Milwaukee Area in response to the need for more advocacy for ovarian cancer awareness and research. Ray of hope provides philanthropic support to ovarian cancer researchers like us to generate preliminary data to apply for high-risk and high-reward federal grants. Ray of hope believes in the bravery of all women who have fought or are fighting against ovarian cancer. Ray of hope is working for women around the globe to be brave and resilient in the fight against ovarian cancer – – and their bravery should not go unnoticed.

Sunila Pradeep, PhD’s laboratory is partnering in the mission of Ray of Hope by identifying novel targets and treatment strategies to cure ovarian cancer.

Sep
29
Wed
2021
Professional Development Series – “Turning your Scholarly Activity into Academic Currency” – Jillian Theobald, MD, PhD , September 29th @ Virtual Invite via Outlook
Sep 29 @ 9:00 am – 10:00 am

The Department of Obstetrics & Gynecology invites you to our 2021-2022 Professional Development Series

Guest Speaker:

Jillian Theobald, MD, PhD
Associate Professor and Medical Toxicology
Department of Emergency Medicine at the Medical College of Wisconsin

Jillian Theobald, MD, PhD is an Associate Professor of Emergency Medicine and Medical Toxicology at the Medical College of Wisconsin. She is the Medical Director of the Adult Translational Research Unit in the Clinical & Translational Science Institute and the Associate Medical Director of the Wisconsin Poison Center. She is the scholarship lead for the Women’s Faculty Council in the department of EM.

She is going to introduce you to how the women in the Department of EM have worked together to increase their scholarly activity and academic currency through monthly meetings, small writing work groups and a vital project dashboard.

Oct
21
Thu
2021
Professionalism Week 2021: Navigating Pandexit – Rebounding from Individual and Collective Challenges @ Virtual Event (register below)
Oct 21 @ 9:00 am – 10:00 am
Professionalism Week 2021: Navigating Pandexit - Rebounding from Individual and Collective Challenges @ Virtual Event (register below)

Please join us as we discuss how groups can successfully navigate collective trauma with the COVID-19 pandemic as a model. It is how we cultivate resilience as a group, foster communication and individually and collectively recover and grow that determines whether an initial trauma will cause additional fall out. We propose to review some best practices for how to collectively navigate “pandexit” or recovery from any traumatic or stressful situation that affects a large group of people. In this session, we will discuss individual and group tools for resilience, go over acute and chronic reactions to trauma and discuss how leadership can steer groups of people into recovery.

Speakers:

      Kate Dielentheis, MD, assistant professor of obstetrics and gynecology
      Kristy Graettinger, MD, associate professor of obstetrics and gynecology
      Abbey Kruper, PsyD, associate professor of obstetrics and gynecology, psychiatry and behavioral medicine